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Table 2 Benchmark mutation coverage.

From: Identifying Mendelian disease genes with the Variant Effect Scoring Tool

  Benchmark
Method Disease Neutral
VEST 100% 100%
PolyPhen2 89% 88%
SIFT4.0 57% 94%
All 3 51% 84%
  1. Percentage of the benchmark test set mutations that could be scored by each of the methods compared.