A protein domain-centric approach for the comparative analysis of human and yeast phenotypically relevant mutations

Table 6 Selected functional feature sites containing domain hotspots in yeast and human

Functional Feature Name	Position-based Domain Hotspots in Yeast	Position-based Domain Hotspots inHuman
ABC transporter signature motif	1	2
Activation loop (A-loop)	4	99
Active site	28	32
ATP binding site	19	13
Ca2+ binding site	1	2
GTP/Mg2+ binding site	3	7
G1 box	3	6
Substrate binding site	5	17

Functional features found to contain position-based hotspots in human and yeast (using a DS-Score threshold of 1.3 to define the domain hotspots).

ISSN: 1471-2164