Figure 2

Distribution of missense mutations in COSMIC and dbSNP. (A) Most somatic non-synonymous mutations in COSMIC were identified in only one tumor sample. 7% of missense mutations were identified in two or more cancer samples. (B) In the dbSNP database global minor allele frequencies are provided for single nucleotide polymorphisms that were identified in the 1000 genomes project. 10% of the missense mutations have a minor allele frequency of 0.25 or higher, which increases their likelihood to be neutral.