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Table 2 Percentage of silent, truncating and functional mutations affecting genes with one copy loss.

From: Revealing selection in cancer using the predicted functional impact of cancer mutations. Application to nomination of cancer drivers

Cancer silent mutation truncating mutation P-value all missense mutations Missense mutations selected by FIS
      FIS>2 FIS>2.5 FIS>3.0 FIS>3.5 P-val
breast 11.6 16.7 0 12.5 12.9 13.4 14.2 16.3 2E-06
lung 11.4 13.5 2E-05 11.7 12.1 12.4 12.5 12.5 0.009
colon 10.7 13.6 0.001 11.5 12.4 13.3 14.2 15.2 3E-04
kidney 6.1 14.3 0 6.5 11.3 12.1 11.4 10.9 2E-04
brain 12.5 15.3 9E-06 13.9 14.1 14.6 15.0 14.6 0.009
overian 20.5 30 0 22.3 23.6 26.2 26.0 29.0 0
  1. Predicted high-scoring functional missense mutations tend to be selected in genes with one copy loss practically as frequent as truncating mutations.
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