Table 1 Predicted driver mutations and core pathways for hypoxia tolerance in Drosophila melanogaster from multiple evidences.
Mutated Gene (Annotation Symbol) | Molecular Function | FDR Corrected p-value for the overrepresentation of signaling pathways | Shortest-path Distance (z-score) up/down | Functional role of nsSNP inferred from structural modeling | Expected accuracy (%) of non-neutral mutation from SNAP[6] | Human ortholog and hypoxia association | |||
|---|---|---|---|---|---|---|---|---|---|
| Â | Â | Up-regulation | Down-regulation | Â | Â | Â | Â | ||
| Â | Â | Notch* | Gurken/EGFR | Toll | Torso/RTK | Â | Â | Â | Â |
Hairless (CG5460) | transcription corepressor | 1.01e-5 | 2.50e-3 | 8.23e-3 | 5.76e-5 | 2.44/4.42 | Possible DNA binding | 82 | Yes [31] |
Rad51D (CG6318) | DNA-dependent ATPase | 3.36e-2 | 1.20e-2 | 1.95e-2 | 1.42e-3 | 2.54/4.09 | PPI | <50 | Yes [30] |
Ulp1 (CG12359) | SUMO-specific protease | 4.68e-2 | 1.87e-2 | >0.05 | >0.05 | 1.78/3.86 | unknown | 63 | Yes [43] |
Wnt5 (CG6407) | receptor binding | 2.67e-2 | 1.97e-3 | 1.06e-2 | 1.16e-7 | 1.26/3.41 | unknown | 58 | |
HDAC4 (CG1770) | histone deacetylase 4 | 2.70e-2 | 4.10e-4 | >0.05 | 5.76e-5 | 1.11/3.13 | AR of catalytic activity | <50 | Yes [34] |
Sol (CG1391) | calcium-dependent cysteine-type endopeptidase | 1.51e-2 | 1.69e-2 | 1.55e-2 | 2.11e-3 | 0.33/2.82 | unknown | <50 | unknown |
Dys (CG34157) | Dystrophin | 8.28e-5 | 8.05e-5 | >0.05 | 3.17e-3 | 0.38/0.72 | AR of substrate binding | 70 | |
GalNAc-T2 (CG6394) | N-acetylgalactosaminyl transferase | 2.59e-3 | 2.71e-10 | 1.30e-2 | 3.28e-3 | -1.51/0.81 | AR of substrate binding | <50 | Yes [35] |
CG33714 (CG33714) | mRNA binding | 8.59e-5 | 5.61e-3 | 1.51e-2 | >0.05 | -1.59/0.69 | mRNA binding | 87 | unknown |