Table 1 Gene Ontology (GO) terms significantly enriched in illicit drugs' target genes compared to non-illicit drugs' target genes in the full drug-target network
From: Exploring drug-target interaction networks of illicit drugs
GO ID | GO terma | # of illicit drugs' target genes (%b) | # of non-illicit drugs' target genes (%c) | p-valued |
|---|---|---|---|---|
GO:0060089 | MF: Molecular transducer activity | 55 (75.3) | 281 (22.8) | < 2.2 × 10-16 |
GO:0007154 | BP: Cell communication | 58 (79.5) | 441 (35.7) | 1.5 × 10-13 |
GO:0005215 | MF: Transporter activity | 38 (52.1) | 215 (17.4) | 9.9 × 10-11 |
GO:0065007 | BP: Biological regulation | 63 (86.3) | 628 (50.9) | 7.9 × 10-10 |
GO:0032501 | BP: Multicellular organismal process | 50 (68.5) | 509 (41.2) | 7.7 × 10-6 |
GO:0051179 | BP: Localization | 45 (61.6) | 461 (37.3) | 5.8 × 10-5 |
GO:0043167 | MF: Ion binding | 35 (47.9) | 432 (35.0) | 0.032 |