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Table 1 Gene Ontology (GO) terms significantly enriched in illicit drugs' target genes compared to non-illicit drugs' target genes in the full drug-target network

From: Exploring drug-target interaction networks of illicit drugs

GO ID GO terma # of illicit drugs' target genes (%b) # of non-illicit drugs' target genes (%c) p-valued
GO:0060089 MF: Molecular transducer activity 55 (75.3) 281 (22.8) < 2.2 × 10-16
GO:0007154 BP: Cell communication 58 (79.5) 441 (35.7) 1.5 × 10-13
GO:0005215 MF: Transporter activity 38 (52.1) 215 (17.4) 9.9 × 10-11
GO:0065007 BP: Biological regulation 63 (86.3) 628 (50.9) 7.9 × 10-10
GO:0032501 BP: Multicellular organismal process 50 (68.5) 509 (41.2) 7.7 × 10-6
GO:0051179 BP: Localization 45 (61.6) 461 (37.3) 5.8 × 10-5
GO:0043167 MF: Ion binding 35 (47.9) 432 (35.0) 0.032
  1. aGene Ontology domains: BP (biological process) and MF (molecular function).
  2. bThe proportion of illicit drugs' target genes belong to a given GO Slim term among the 73 illicit drugs' target genes.
  3. cThe proportion of non-illicit drugs' target genes belong to a given GO Slim term among the 1235 non-illicit drugs' target genes.
  4. dp-value was calculated by Fisher's exact test.