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Table 3 ATC second sublevel categories significantly enriched in illicit-related drugs compared to other drugsa

From: Exploring drug-target interaction networks of illicit drugs

ATC code ATC therapeutic subgroup # of illicit-related drugs (%b) # of other drugs (%c) p-value
N05 Psycholeptics 54 (14.8) 3 (0.5) 1.4 × 10-20
N06 Psychoanaleptics 38 (10.4) 4 (0.7) 6.7 × 10-13
N01 Anesthetics 25 (6.9) 0 (0) 1.9 × 10-11
D07 Corticosteroids, dermatological preparations 23 (6.3) 0 (0) 1.4 × 10-10
N04 Anti-Parkinson drugs 17 (4.7) 2 (0.3) 4.2 × 10-6
G03 Sex hormones and modulators of the genital system 21 (5.8) 5 (0.8) 1.1 × 10-5
H02 Corticosteroids for systemic use 12 (3.3) 1 (0.2) 7.0 × 10-5
N07 Other nervous system drugs 14 (3.8) 5 (0.8) 2.9 × 10-3
A03 Drugs for functional gastrointestinal disorders 14 (3.8) 5 (0.8) 2.9 × 10-3
C05 Vasoprotectives 12 (3.3) 4 (0.7) 3.2 × 10-3
R01 Nasal preparations 16 (4.4) 7 (1.2) 3.6 × 10-3
S01 Ophthalmologicals 43 (11.8) 44 (7.4) 0.027
  1. aThe other drugs represent the drugs in the full drug-target network excluding illicit drugs and illicit-related drugs. Among those other drugs, 594 have ATC second sublevel classifications.
  2. bThe proportion of illicit drugs belong to a given ATC category among the 365 illicit-related drugs with ATC second sublevel classifications.
  3. cThe proportion of other drugs belong to a given ATC category among the 594 other drugs.
  4. dp-value was calculated by Fisher's exact test.