Co-modulated behavior and effects of differentially expressed miRNA in colorectal cancer

BMC Genomics

Table 2 Target genes of 15 dysregulated miRNA were selected for RT-PCR examination in this study

Target type	Group	Gene Symbol	miRNA	Expression level in colon cancer^#
predicted	Group I	GDNF	miR133a, miR9	Down**
	miRNA ↓	MYH9	miR133a, miR9	Up*
		RNF111	miR1, miR9	Down*
	GroupII	GNA13	miR182, miR96	Down*
	miRNA ↑	HBEGF	miR182, miR96	Down***
		LAMC1	miR182, miR96	Up***
		PPP2R3A	miR182, miR96	Down***
known	Group III	Bim	miR10b	NS
	miRNA ↓	CDC42	miR1	NS
		collagen I	miR143	Up***
		CyclinD1	miR1	Up**
		PDGFRB	miR9	NS
		PPP2CA	miR133	NS
		Versican	miR9	Up**
		calmodulin	miR196a, miR143	NS
	Group IV	ATM	miR18a	NS
	miRNA ↑	FBXW7	miR182	NS
		FZD3	miR31, miR182	NS
		SMAD2	miR18a	Up**
	Group V	CREB1	miR10b, miR182	Up***
		FBXW11	miR133, miR96, miR182	NS
	Mixed	IGF1	miR1, miR18a	Down***
		MAP3K14	miR137, miR31	NS
		MSN	miR133a, miR96	Up***
		PDGFRA	miR342, miR182	NS
		SMAD4	miR1, miR224	NS
		RASA1	miR1, miR96, miR182, miR31	NS

# Paired t test results: NS: not significant, * P < 0.05, ** P <0.01, *** P < 0.001

ISSN: 1471-2164