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Table 2 Target genes of 15 dysregulated miRNA were selected for RT-PCR examination in this study

From: Co-modulated behavior and effects of differentially expressed miRNA in colorectal cancer

Target type

Group

Gene Symbol

miRNA

Expression level in colon cancer#

predicted

Group I

GDNF

miR133a, miR9

Down**

 

miRNA

MYH9

miR133a, miR9

Up*

  

RNF111

miR1, miR9

Down*

 

GroupII

GNA13

miR182, miR96

Down*

 

miRNA

HBEGF

miR182, miR96

Down***

  

LAMC1

miR182, miR96

Up***

  

PPP2R3A

miR182, miR96

Down***

known

Group III

Bim

miR10b

NS

 

miRNA

CDC42

miR1

NS

  

collagen I

miR143

Up***

  

CyclinD1

miR1

Up**

  

PDGFRB

miR9

NS

  

PPP2CA

miR133

NS

  

Versican

miR9

Up**

  

calmodulin

miR196a, miR143

NS

 

Group IV

ATM

miR18a

NS

 

miRNA

FBXW7

miR182

NS

  

FZD3

miR31, miR182

NS

  

SMAD2

miR18a

Up**

 

Group V

CREB1

miR10b, miR182

Up***

  

FBXW11

miR133, miR96, miR182

NS

 

Mixed

IGF1

miR1, miR18a

Down***

  

MAP3K14

miR137, miR31

NS

  

MSN

miR133a, miR96

Up***

  

PDGFRA

miR342, miR182

NS

  

SMAD4

miR1, miR224

NS

  

RASA1

miR1, miR96, miR182, miR31

NS

  1. # Paired t test results: NS: not significant, * P < 0.05, ** P <0.01, *** P < 0.001