Figure 6
From: Genome-wide structural modelling of TCR-pMHC interactions
Detailed binding model of TCR-peptide interface of template (i.e. Tax-1) and amino acid compositions of its corresponding peptide antigen families derived from iMatrix and one-matrix. (A) Detailed binding model of TCR-peptide interface of Tax-1 (11-19 LLFGFPVYV of UniProt accession number: P0C213) by using the template (PDB entry: 1bd2). The amino acid composition (profiles) of the homologous peptide antigens derived from the (B) iMatrix and (C) one-matrix. (D) The 13 positive hits, recorded in the IEDB derived from iMatrix scoring function, are consensus (i.e. Tyr) in the position 5. The position 5 of 6 novel homologous peptides are the resdiue Tyr.