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Table 2 MED lowest-scored proteins.

From: Mature Epitope Density - A strategy for target selection based on immunoinformatics and exported prokaryotic proteins

Genome
Locus
N d MED
(nM/mer)
Local Evidence Unique publication identifier
Rv0532 59 555 3,19 SEC contrary 10.1021/pr1005108
Rv0746 77 741 3,11 SEC contrary 10.1186/1471-2148-6-95, 10.1016/j.micinf.2006.03.015
Rv1468c 37 328 3,03 SEC contrary 10.1021/pr1005108
Rv3590c 48 542 2,96 SEC favorable 10.1016/S1672-0229(08)60039-X
Rv3511 66 678 2,91 SEC favorable 10.1186/1471-2148-6-95
Rv1100 20 160 2,88 PSE contrary 10.1099/mic.0.27204-0
Rv3312A 4 64 2,69 SEC contrary 10.1073/pnas.0602304104
Rv3595c 34 400 2,51 SEC contrary 10.1186/1471-2148-6-95
Rv1091 60 814 2,40 SEC contrary 10.1186/1471-2148-6-95
Rv3706c 4 50 2,32 PSE contrary 10.3389/fmicb.2010.00121
Rv3345c 98 1498 2,05 SEC favorable 10.1186/1471-2148-6-95, 10.1099/mic.0.26660-0
Rv0559c 4 78 2,05 SEC contrary 10.1371/journal.pone.0007615
Rv3388 44 690 2,03 SEC contrary 10.1016/j.tube.2003.12.014
Rv0833 52 689 1,75 PSE favorable 10.1186/1471-2148-6-95
Rv2487c 28 655 1,15 SEC contrary Patent EP2207035
Rv3514 43 1448 0,93 SEC contrary 10.1111/j.1365-2567.2010.03383.x
Rv3508 40 1860 0,71 SEC contrary 10.1371/journal.pone.0002375, 10.1002/prot.10586
Rv3655c 0 0 0 PSE contrary 10.1371/journal.pone.0010474
  1. Table 2 lists 18 of the 30 MED lowest-scored proteins from the Mtb H37Rv exported proteins. Each protein is accompanied by at least a unique publication identifier, which can be doi, Pubmed id or a patent number. A protein can be cited twice or thrice by different publications; some publications cite several proteins. The first columns in Tables 1 and 2 show the protein locus tags, followed by the number of predicted epitopes (n) and epitope probability as a function of its proportion in the mature protein (d). The MED score is calculated as n divided by d. Evidence can be favorable or contrary based on publication results and the expectation indicated by the MED score.