Figure 7
From: Functional chromatin features are associated with structural mutations in cancer
Enrichment metrics as a function of distance in the Breast-Stephens SM callset. Two enrichment metrics: fraction of coverage (left) and odds ratio (right) as a function of distance. Each bin on the horizontal axis is defined as a “range”, e.g. a marker between 100 kb and 200 kb depicts enrichment in regions >100 kb but <200 kb from the nearest SM breakpoint. A. Observed fraction of ChIP-seq (Pol II, GM12878, SYDH) coverage falling within given distance range of SM breakpoints (thick line) vs. the fraction expected to fall based on the total size of the genome in each bin. B. Enrichment odds ratio for ChIP-seq peaks (Pol II, GM12878, SYDH). C. Observed fraction of DNaseI peaks (HeLaS3, Duke) falling within given distance of SM breakpoints (thick line) vs. the fraction expected to fall based on the total size of the genome in each bin. D. Enrichment odds ratio for DNaseI peaks (HeLaS3, Duke). E. Observed fraction of FAIRE peaks (HeLaS3, UNC) falling within given distance of SM breakpoints (thick line) vs. the fraction expected to fall based on the total size of the genome in each bin. F. Enrichment odds ratio for FAIRE peaks (HeLaS3, UNC).