An overlook of stress/defense related proteins and ROS scavenging system involved in wheat grain development. LEA, TLP, SLP, CAP, CRP Emp and wail17 have coordinating role in various osmotic stresses during grain development. αAI and XI are mainly involved in protection of starch and cell wall, respectively. Purothionin, antifungal protein R (APR), chltinase, rRNA N-glycosidase (rRNA N-g) and wheatwin2 were mainly involved in resistance to pathogen and pest infection. Serpin, CTI and Hsps are involved in protein protection processes, serpin and CTI prevent protein from degradation by protese, Hsps prevent degraded protein from aggregation and help misfolded protein refolding, these processes also involved in resistance to pathogen/insect and osmotic stress. All defense process can produce reactive oxygen and which can be scavenged by ROS scavenging system. The protein levels are shown in coloured squares, indicating the change of expression for each developmental stage. The phosphorylated DEPs are marked.