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Table 1 Genes over- and under-expressed under oxygen conditions (condition O2) for the strain MG1363

From: Early adaptation to oxygen is key to the industrially important traits of Lactococcus lactis ssp. cremoris during milk fermentation

NomSpot

COG number

COG functional categories

Gene name

Gene product

1 h

5 h

8 h

llmg_1464

COG3527

Q

aldC

alpha-acetolactate decarboxylase

4.59

  

llmg_1309

COG0028

EH

als

acetolactate synthase large subunit

3.64

  

llmg_1700

COG4608

E

choQ

choline ABC transporter ATP binding protein

3.21

  

llmg_1699

COG1732

M

choS

choline ABC transporter permease and substrate binding protein

3.61

  

llmg_1737

COG0596

R

cpo

non-heme chloride peroxidase

2.27

  

llmg_0346

COG1118

P

fhuC

ferrichrome ABC transporter fhuC

4.28

  

llmg_0349

COG0614

P

fhuD

ferrichrome ABC transporter substrate binding protein

5.67

  

llmg_0348

COG0609

P

fhuG

ferrichrome ABC transporter permease protein

4.15

  

llmg_1702

COG1249

C

gshR

glutathione reductase

3.00

  

llmg_0274

  

llmg_0274

conserved hypothetical protein

4.67

  

llmg_0276

COG0656

R

llmg_0276

oxidoreductase, aldo/keto reductase family

3.52

  

llmg_0281

COG1328

F

llmg_0281

anaerobic ribonucleoside-triphosphate reductase

6.11

  

llmg_2143

COG1302

S

llmg_2143

putative 20-kDa protein

3.24

  

llmg_2144

  

llmg_2144

hypothetical protein predicted by Glimmer/Critica

5.30

  

llmg_2145

  

llmg_2145

conserved hypothetical protein

5.27

  

llmg_0075

COG0095

H

lplL

lipoate-protein ligase

8.38

  

llmg_1828

COG1169

HQ

menF

menaquinone-specific isochorismate synthase

2.69

  

llmg_0951

COG0225

O

msrA

peptide methionine sulfoxide reductase

2.52

  

llmg_1970

COG0822

C

nifU

conserved hypothetical protein

4.33

  

llmg_0408

COG0446

R

noxE

NADH oxidase

22.93

  

llmg_1543

COG0209

F

nrdE

ribonucleoside-diphosphate reductase alpha chain

16.70

  

llmg_1544

COG0208

F

nrdF

ribonucleoside-diphosphate reductase beta chain

5.63

  

llmg_0282

COG0602

O

nrdG

anaerobic ribonucleoside-triphosphate reductase activating protein

4.30

  

llmg_1541

COG0695

O

nrdH

Glutaredoxin-like protein nrdH.

10.25

  

llmg_1542

COG0716

C

nrdI

Ribonucleotide reductase NrdI

12.93

  

llmg_0074

COG1071

C

pdhA

pyruvate dehydrogenase E1 component alpha subunit

5.96

  

llmg_0073

COG0022

C

pdhB

pyruvate dehydrogenase E1 component beta subunit

5.03

  

llmg_0072

COG0508

C

pdhC

pyruvate dehydrogenase complex E2 component

5.65

  

llmg_0071

COG1249

C

pdhD

pyruvate dehydrogenase complex E3 component

2.84

  

llmg_0629

COG1882

C

pfl

formate acetyltransferase

 

2.97

 

llmg_0318

COG2077

O

tpx

thiol peroxidase

4.18

  

llmg_0776

COG0492

O

trxB2

thioredoxin reductase

4.28

  

NomSpot

COG number

COG functional categories

Gene name

Gene product

1 h

5 h

8 h

llmg_2432

COG1012

C

adhE

alcohol-acetaldehyde dehydrogenase

−7.45

  

llmg_0100

COG2217

P

cadA

cation-transporting ATPase

−4.06

  

llmg_1865

COG3104

E

dtpT

di-/tripeptide transporter

−2.11

  

llmg_0758

COG0038

P

eriC

Putative chloride channel protein.

−2.04

  

llmg_1551

COG2116

P

fdhC

putative formate dehydrogenase

−2.76

  

llmg_1441

COG1053

C

frdC

fumarate reductase flavoprotein subunit

−4.24

  

llmg_0993

COG0634

F

hprT

hypoxanthine-guanine phosphoribosyltransferase

−2.01

  

llmg_1915

COG0247

C

llmg_1915

putative Fe-S oxidoreductase

−3.61

  

llmg_0447

COG0674

C

nifJ

Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit

−11.19

  

llmg_1514

COG2344

R

rex

Redox-sensing transcriptional repressor rex.

−2.73

  

llmg_0640

COG1393

P

trmA

Regulatory protein spx

−2.15

  

llmg_0429

COG0605

P

sodA

superoxide dismutase

 

−3.08

 

llmg_1362

  

orf44

hypothetical protein predicted by Glimmer/Critica

 

−2.28

 

llmg_1376

COG4227

L

ltrC

LtrC

  

−2.61

llmg_1377

  

orf30

hypothetical protein predicted by Glimmer/Critica

  

−2.09

llmg_1378

  

orf29

hypothetical protein predicted by Glimmer/Critica

  

−2.10

llmg_1379

COG2856

E

orf28

Predicted Zn peptidase

  

−2.06

llmg_1384

  

orf24

hypothetical protein predicted by Glimmer/Critica

  

−2.11

llmg_1387

COG5179

K

orf21

hypothetical protein predicted by Glimmer/Critica

 

−2.12

 

llmg_1399

  

orf10

hypothetical protein predicted by Glimmer/Critica

−2.37

  

llmg_1402

  

orf8

hypothetical protein predicted by Glimmer/Critica

  

−2.03

  1. Fold-changes of selected differentially expressed genes of the strain MG1363 in O2 condition in comparison with N2 condition, from a whole-genome microarray analysis (n = 3). Genes were significantly (p-value < 0.5) differentially expressed with a FDR < 0.5 and a |fold-change| > 2. Top table is over-expressed genes; bottom table is under-expressed genes. Under-expressed genes; the ninth last genes are involved in the conjugation.