Novel and unique domains in aminoacyl-tRNA synthetases from human fungal pathogens Aspergillus niger, Candida albicans and Cryptococcus neoformans

Table 2 ORFs in C. albicans having aaRS or associated domains

	aaRS domain	ORF	Predicted sub-cellular localization	Protein length	E-value for HMM prediction	Identity with human homolog (%)
Class I	ArgRS	orf19.3341	Cyto	622	1.2e-104	38
	CysRS	orf19.4931	Mito	781	0	42
	GlnRS	orf19.7064	Cyto	799	0	38
	GluRS	orf19.2415	Mito	509	1.9e-199	35
	GluRS	orf19.7057	Cyto	725	NA	42
	IleRS	orf19.2138	Nucl	1088	0	53
	IleRS	orf19.2382	Mito	973	0	36
	LeuRS	orf19.2560	Cyto	1097	0	46
	LeuRS	orf19.5705	Cyto	861	0	37
	MetRS	orf19.3955	Cyto	748	0	51
	TrpRS	orf19.5226	Cyto	424	3e-235	56
	TrpRS	orf19.4299	Nucl	399	4.8e-156	42
	TyrRS	orf19.2694	Cyto	409	3.8e-170	53
	TyrRS	orf19.109	Mito	501	7.3e-152	34
	ValRS	orf19.1295	Mito	1119	0	48
Class II	AlaRS	orf19.5746	Cyto	969	0	50
	AsnRS	orf19.6698	Mito	489	6.2e-146	35
	AspRS	orf19.4478	Mito	698	5.5e-173	35
	AsxRS	orf19.2407	Cyto	578	0	58
	AsxRS	orf19.6702	Cyto	552	1.3e-261	52
	GlyRS	orf19.437	Nucl	652	0	50
	HisRS	orf19.4051	Mito	501	2.3e-271	52
	LysRS	orf19.6749	Nucl	594	0	56
	PheRS	orf19.2039	Mito	446	8.8e-218	39
	PheRS α	orf19.2960	Cyto	496	3.2e-244	47
	PheRS β	orf19.2573	Cyto_nucl	592	1.1e-284	45
	ProRS	orf19.6701	Cyto	691	0	57
	SerRS	orf19.269	Nucl	458	3.8e-245	46
	ThrRS	orf19.5685	Nucl	706	0	59
aaRS related proteins	DTD2	orf19.297	Cyto	163	NA	48
	AlaX	orf19.5239	Cyto_nucl	471	2.1e-127	31
	P43 homolog	orf19.2422	Cyto	369	1.9e-130	53
	Asn synthase	orf19.3626	Nucl	704	1e-178	25
	Asn synthase	orf19.198	Cyto	573	1.1e-58	35
	GatA	orf19.3956	Mito	450	1.7e-135	34
	GatB	orf19.2494	Nucl	488	9.7e-141	32
	GatF	orf19.4092	Nucl	165	NA	NA

NA in e-value indicates fungal sequences that could be identified by HMM search and were retrieved from NCBI using keyword search.

ISSN: 1471-2164