Pearson’s correlation analysis. Significantly (sig.) upregulated genes (FDR ≤ 0.05) identified in primary hepatocytes (PH) treated with Wy14643 for 6 or 24 h and precision cut liver slices (PCLS) treated with Wy14643 for 24 h were correlated with corresponding genes in livers (L) of mice treated with Wy14643 for 6 h (A-C) or 5 days (5d), D-F). Significantly downregulated genes (FDR ≤ 0.05) identified in PCLS 24 h were correlated with corresponding genes in L6 h (G) or L5d (H). Each dot represents the average (avg.) log2 value of fold change (FC) in gene expression of treatment group vs. control. All correlations were significant at P ≤ 0.01, with the exception of 3G and 3H.