Transcription factor MrpC binds to promoter regions of hundreds of developmentally-regulated genes in Myxococcus xanthus

Table 2 Comparison of known MrpC targets with ChIP-seq analysis

Gene	MXAN	MrpC target	ChIP-seq peak (rank^a)	Reference
mrpC	5125	Yes	Yes (6)	[44]
fruA	3117	Yes	Yes (14)^b	[30, 44]
dev	7265	Yes	Yes (534)	Unpublished data^d
fmgD	1501	Yes	Yes (1358)	[45]
fmgBC	4126	Yes	Yes/No^c	[47]
dev	7266	Yes	Yes/No	[53]
fmgA	2884	Yes	No	[46]
fmgE	3464	Yes	No	[48]
fdgA	3225	No	No	[55]

^aFor genes exhibiting a significantly-enriched ChIP-seq peak in both samples, the peak rank among 1608 peaks in Additional file 3 is given in parentheses.
^bThe ChIP-seq peak matched the position of previously-characterized binding sites for MrpC2 that were shown to be important for fruA expression [30], although the ChIP-seq peak was closer to the predicted translation start codon of MXAN_3116 (Additional file 3), which is upstream of fruA in divergent orientation.
^cA significantly-enriched peak was observed in one of the two samples subjected to ChIP-seq analysis.
^dA. Campbell, L. Kroos.

ISSN: 1471-2164