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Table 2 Selected differentially expressed genes in fast muscle of exercised zebrafish that participate in the contractile activation of skeletal muscle fibers

From: Swimming-induced exercise promotes hypertrophy and vascularization of fast skeletal muscle fibres and activation of myogenic and angiogenic transcriptional programs in adult zebrafish

Gene name gene description

FC

Gene name gene description

FC

Muscle contraction

 

Muscle growth and development

 

capn8

Calpain 8

4.11

fgf20

Fibroblast growth factor 20

8.94

actn4

Actinin, alpha 4

3.99

hdac6

Histone deacetylase 6

6.42

myh11

Myosin, heavy chain 11, smooth muscle

3.63

fgf18

Fibroblast growth factor 18

6.30

camk2n2

Ca/calmodulin-dependent protein kinase II inhibitor 2

3.38

wnt10a

Wingless-type MMTV integration site, 10A

6.25

pvalb

Parvalbumin

3.24

pax3

Paired box 3

6.21

tnni2

Troponin I type 2 (skeletal, fast)

3.12

tgfb2

Transforming growth factor, beta 2

5.35

capn3

Calpain 3, (p94)

3.08

nog

Noggin

4.90

nfatc4

Nuclear factor of activated T-cells, calcineurin-dep. 4

3.08

esrra

Estrogen-related receptor alpha

4.73

capn2

Calpain 2, (m/II) large subunit

2.92

wnt7a

Wingless-type MMTV integration site, 7A

4.60

tmod4

Tropomodulin 4 (muscle)

2.79

mstn

Myostatin

4.41

nfatc1

Nuclear factor of activated T-cells, , calcineurin-dep. 1

2.76

foxa1

Forkhead box A1

4.22

capzb

Capping protein (actin filament) muscle Z-line, beta

2.75

fgfr2

Fibroblast growth factor receptor 2

4.05

casq1

Calsequestrin 1 (fast-twitch, skeletal muscle)

2.68

shh

Sonic hedgehog

3.78

myl2

Myosin, light chain 2, regulatory, cardiac, slow

2.64

fzd2

Frizzled family receptor 2

3.08

ppp3cc

Protein phosphatase 3, catalytic subunit, gamma

2.61

pik3c2b

Phosphatidylinositol-4-p- 3-kinase c2b

3.06

capn5

Calpain 5

2.60

fgf13

Fibroblast growth factor 13

3.01

ttn

Titin

2.58

mapk1

Mitogen-activated protein kinase 1

3.00

ppp3ca

Protein phosphatase 3, catalytic subunit, alpha isozyme

2.52

fzd10

Frizzled family receptor 10

2.94

mylpf

Myosin light chain, phosphorylatable, fast skel. muscle

2.26

ihh

Indian hedgehog

2.91

mybph

Myosin binding protein H

2.17

fzd8

Frizzled family receptor 8

2.87

capn10

Calpain 10

2.15

esrrb

Estrogen-related receptor beta

2.61

cacna1s

Calcium channel, voltage-dependent, L type, alpha 1S

2.11

bmpr1a

Bone morphogenetic protein receptor, IA

2.58

camk2a

Calcium/calmodulin-dependent protein kinase II alpha

1.98

ngf

Nerve growth factor (beta polypeptide)

2.55

camk2d

Calcium/calmodulin-dependent protein kinase II delta

1.97

igf1r

Insulin-like growth factor 1 receptor

2.53

nfatc3

Nuclear factor of activated T-cells, calcineurin-dep. 3

1.92

bmp1

Bone morphogenetic protein 1

2.46

acta2

Actin, alpha 2, smooth muscle, aorta

1.92

dvl1

Dishevelled, dsh homolog 1 (Drosophila)

2.43

mylk

Myosin light chain kinase

1.87

smad2

SMAD family member 2

2.40

tpm4

Tropomyosin 4

1.78

bmp4

Bone morphogenetic protein 4

2.38

myl9

Myosin, light chain 9, regulatory

1.77

igfbp7

Insulin-like growth factor binding protein 7

2.36

ryr1

Ryanodine receptor 1 (skeletal)

1.77

esrrg

Estrogen-related receptor gamma

2.36

tpm1

Tropomyosin 1 (alpha)

1.71

bmpr1b

Bone morphogenetic protein receptor, IB

2.27

atp2a1

ATPase, Ca transporting, cardiac muscle, fast twitch 1

1.70

erbb2

v-erb-b2 erythroblastic leukemia. 2

2.27

actc1

Actin, alpha, cardiac muscle 1

1.68

mapk13

Mitogen-activated protein kinase 13

2.23

cacng1

Calcium channel, voltage-dependent, gamma subunit 1

1.61

fst

Follistatin

2.17

myl12b

Myosin, light chain 12B, regulatory

−1.59

mapk8

Mitogen-activated protein kinase 8

2.12

s100a4

S100 calcium binding protein A4

−1.63

smad6

SMAD family member 6

2.06

calm1

Calmodulin 1 (phosphorylase kinase, delta)

−2.04

fgfr1

Fibroblast growth factor receptor 1

1.96

actg2

Actin, gamma 2, smooth muscle, enteric

−3.87

irs2

Insulin receptor substrate 2

1.91

tnnt3

Troponin T type 3 (skeletal, fast)

−7.01

runx2

Runt-related transcription factor 2

1.90

Cytoskeleton

 

igfbp1

Insulin-like growth factor binding protein 1

1,89

ank2

Ankyrin 2, neuronal

11.01

irs1

Insulin receptor substrate 1

1.78

plec

Plectin

3.31

acvr2b

Activin A receptor, type IIB

1.74

myoz1

Myozenin 1

2.41

tgfb1

Transforming growth factor, beta 1

1.71

myoz2

Myozenin 2

2.28

mef2d

Myocyte enhancer factor 2D

1.71

dag1

Dystroglycan 1 (dystrophin-associated glycoprotein 1)

2.26

hdac4

Histone deacetylase 4

1.71

itgb4

Integrin, beta 4

1.99

igfbp3

Insulin-like growth factor binding protein 3

1.66

itga2b

Integrin, alpha 2b

1.95

mef2a

Myocyte enhancer factor 2A

1.66

dmd

Dystrophin

1.94

igf2

Insulin-like growth factor 2

1.61

filip1

Filamin A interacting protein 1

1.88

pten

Phosphatase and tensin homolog

−1.54

sntb1

Syntrophin, beta 1 (dystrophin-associated protein A1)

1.78

mef2c

Myocyte enhancer factor 2C

−1.59

vim

Vimentin

1.61

egfr

Epidermal growth factor receptor

−2.13

lmna

Lamin A/C

−1.51

id3

Inhibitor of DNA binding 3

−2.39

dtnbp1

Dystrobrevin binding protein 1

−1.76

srf

Serum response factor

−2.68

flnc

Filamin C, gamma

−1.88

mapk14

Mitogen-activated protein kinase 14

−2.78

Neuromuscular junction

 

Extracelular matrix

 

ache

Acetylcholinesterase

8.86

col8a2

Collagen, type VIII, alpha 2

12.06

vamp1

Vesicle-associated membrane prot. 1 (synaptobrevin1)

3.78

lamc3

Laminin, gamma 3

10.06

chrm2

Cholinergic receptor, muscarinic 2

3.65

col16a1

Collagen, type XVI, alpha 1

6.17

snap25

Synaptosomal-associated protein, 25kDa

3.08

col1a2

Collagen, type I, alpha 2

3.12

scn4b

Sodium channel, voltage-gated, type IV, beta subunit

3.01

bgn

Biglycan

2.98

syn2

Synapsin II

2.70

loxl2

Lysyl oxidase-like 2

2.92

syt1

Synaptotagmin I

2.22

mmp14

Matrix metallopeptidase 14

2.69

rims2

Regulating synaptic membrane exocytosis 2

1.93

tnc

Tenascin C

2.53

scnm1

Sodium channel modifier 1

1.65

mmp10

Matrix metallopeptidase 10 (stromelysin 2)

2.06

syncrip

Synaptotagmin binding, cytoplasmic RNA interact. pro.

−1.54

sdcbp

Syndecan binding protein (syntenin)

−2.26

  1. Data are shown as fold change (FC).
  2. Functional categories are indicated in bold.
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BMC Genomics

ISSN: 1471-2164

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