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Table 2 Selected differentially expressed genes in fast muscle of exercised zebrafish that participate in the contractile activation of skeletal muscle fibers

From: Swimming-induced exercise promotes hypertrophy and vascularization of fast skeletal muscle fibres and activation of myogenic and angiogenic transcriptional programs in adult zebrafish

Gene name gene description FC Gene name gene description FC
Muscle contraction   Muscle growth and development  
capn8 Calpain 8 4.11 fgf20 Fibroblast growth factor 20 8.94
actn4 Actinin, alpha 4 3.99 hdac6 Histone deacetylase 6 6.42
myh11 Myosin, heavy chain 11, smooth muscle 3.63 fgf18 Fibroblast growth factor 18 6.30
camk2n2 Ca/calmodulin-dependent protein kinase II inhibitor 2 3.38 wnt10a Wingless-type MMTV integration site, 10A 6.25
pvalb Parvalbumin 3.24 pax3 Paired box 3 6.21
tnni2 Troponin I type 2 (skeletal, fast) 3.12 tgfb2 Transforming growth factor, beta 2 5.35
capn3 Calpain 3, (p94) 3.08 nog Noggin 4.90
nfatc4 Nuclear factor of activated T-cells, calcineurin-dep. 4 3.08 esrra Estrogen-related receptor alpha 4.73
capn2 Calpain 2, (m/II) large subunit 2.92 wnt7a Wingless-type MMTV integration site, 7A 4.60
tmod4 Tropomodulin 4 (muscle) 2.79 mstn Myostatin 4.41
nfatc1 Nuclear factor of activated T-cells, , calcineurin-dep. 1 2.76 foxa1 Forkhead box A1 4.22
capzb Capping protein (actin filament) muscle Z-line, beta 2.75 fgfr2 Fibroblast growth factor receptor 2 4.05
casq1 Calsequestrin 1 (fast-twitch, skeletal muscle) 2.68 shh Sonic hedgehog 3.78
myl2 Myosin, light chain 2, regulatory, cardiac, slow 2.64 fzd2 Frizzled family receptor 2 3.08
ppp3cc Protein phosphatase 3, catalytic subunit, gamma 2.61 pik3c2b Phosphatidylinositol-4-p- 3-kinase c2b 3.06
capn5 Calpain 5 2.60 fgf13 Fibroblast growth factor 13 3.01
ttn Titin 2.58 mapk1 Mitogen-activated protein kinase 1 3.00
ppp3ca Protein phosphatase 3, catalytic subunit, alpha isozyme 2.52 fzd10 Frizzled family receptor 10 2.94
mylpf Myosin light chain, phosphorylatable, fast skel. muscle 2.26 ihh Indian hedgehog 2.91
mybph Myosin binding protein H 2.17 fzd8 Frizzled family receptor 8 2.87
capn10 Calpain 10 2.15 esrrb Estrogen-related receptor beta 2.61
cacna1s Calcium channel, voltage-dependent, L type, alpha 1S 2.11 bmpr1a Bone morphogenetic protein receptor, IA 2.58
camk2a Calcium/calmodulin-dependent protein kinase II alpha 1.98 ngf Nerve growth factor (beta polypeptide) 2.55
camk2d Calcium/calmodulin-dependent protein kinase II delta 1.97 igf1r Insulin-like growth factor 1 receptor 2.53
nfatc3 Nuclear factor of activated T-cells, calcineurin-dep. 3 1.92 bmp1 Bone morphogenetic protein 1 2.46
acta2 Actin, alpha 2, smooth muscle, aorta 1.92 dvl1 Dishevelled, dsh homolog 1 (Drosophila) 2.43
mylk Myosin light chain kinase 1.87 smad2 SMAD family member 2 2.40
tpm4 Tropomyosin 4 1.78 bmp4 Bone morphogenetic protein 4 2.38
myl9 Myosin, light chain 9, regulatory 1.77 igfbp7 Insulin-like growth factor binding protein 7 2.36
ryr1 Ryanodine receptor 1 (skeletal) 1.77 esrrg Estrogen-related receptor gamma 2.36
tpm1 Tropomyosin 1 (alpha) 1.71 bmpr1b Bone morphogenetic protein receptor, IB 2.27
atp2a1 ATPase, Ca transporting, cardiac muscle, fast twitch 1 1.70 erbb2 v-erb-b2 erythroblastic leukemia. 2 2.27
actc1 Actin, alpha, cardiac muscle 1 1.68 mapk13 Mitogen-activated protein kinase 13 2.23
cacng1 Calcium channel, voltage-dependent, gamma subunit 1 1.61 fst Follistatin 2.17
myl12b Myosin, light chain 12B, regulatory −1.59 mapk8 Mitogen-activated protein kinase 8 2.12
s100a4 S100 calcium binding protein A4 −1.63 smad6 SMAD family member 6 2.06
calm1 Calmodulin 1 (phosphorylase kinase, delta) −2.04 fgfr1 Fibroblast growth factor receptor 1 1.96
actg2 Actin, gamma 2, smooth muscle, enteric −3.87 irs2 Insulin receptor substrate 2 1.91
tnnt3 Troponin T type 3 (skeletal, fast) −7.01 runx2 Runt-related transcription factor 2 1.90
Cytoskeleton   igfbp1 Insulin-like growth factor binding protein 1 1,89
ank2 Ankyrin 2, neuronal 11.01 irs1 Insulin receptor substrate 1 1.78
plec Plectin 3.31 acvr2b Activin A receptor, type IIB 1.74
myoz1 Myozenin 1 2.41 tgfb1 Transforming growth factor, beta 1 1.71
myoz2 Myozenin 2 2.28 mef2d Myocyte enhancer factor 2D 1.71
dag1 Dystroglycan 1 (dystrophin-associated glycoprotein 1) 2.26 hdac4 Histone deacetylase 4 1.71
itgb4 Integrin, beta 4 1.99 igfbp3 Insulin-like growth factor binding protein 3 1.66
itga2b Integrin, alpha 2b 1.95 mef2a Myocyte enhancer factor 2A 1.66
dmd Dystrophin 1.94 igf2 Insulin-like growth factor 2 1.61
filip1 Filamin A interacting protein 1 1.88 pten Phosphatase and tensin homolog −1.54
sntb1 Syntrophin, beta 1 (dystrophin-associated protein A1) 1.78 mef2c Myocyte enhancer factor 2C −1.59
vim Vimentin 1.61 egfr Epidermal growth factor receptor −2.13
lmna Lamin A/C −1.51 id3 Inhibitor of DNA binding 3 −2.39
dtnbp1 Dystrobrevin binding protein 1 −1.76 srf Serum response factor −2.68
flnc Filamin C, gamma −1.88 mapk14 Mitogen-activated protein kinase 14 −2.78
Neuromuscular junction   Extracelular matrix  
ache Acetylcholinesterase 8.86 col8a2 Collagen, type VIII, alpha 2 12.06
vamp1 Vesicle-associated membrane prot. 1 (synaptobrevin1) 3.78 lamc3 Laminin, gamma 3 10.06
chrm2 Cholinergic receptor, muscarinic 2 3.65 col16a1 Collagen, type XVI, alpha 1 6.17
snap25 Synaptosomal-associated protein, 25kDa 3.08 col1a2 Collagen, type I, alpha 2 3.12
scn4b Sodium channel, voltage-gated, type IV, beta subunit 3.01 bgn Biglycan 2.98
syn2 Synapsin II 2.70 loxl2 Lysyl oxidase-like 2 2.92
syt1 Synaptotagmin I 2.22 mmp14 Matrix metallopeptidase 14 2.69
rims2 Regulating synaptic membrane exocytosis 2 1.93 tnc Tenascin C 2.53
scnm1 Sodium channel modifier 1 1.65 mmp10 Matrix metallopeptidase 10 (stromelysin 2) 2.06
syncrip Synaptotagmin binding, cytoplasmic RNA interact. pro. −1.54 sdcbp Syndecan binding protein (syntenin) −2.26
  1. Data are shown as fold change (FC).
  2. Functional categories are indicated in bold.