The known core components and regulators of the TRAIL apoptotic machinery do not predict TRAIL sensitivity with a high degree of sensitivity and specificity. (A) The selected 26 core component genes and regulators of the TRAIL apoptotic. (B) Performance of the 26 “TRAIL effectors” as a classifier assessed using the same approach as for the whole transcriptome (workflow shown in Additional file 1: Figure S1). The 26 core effectors predicted TRAIL sensitivity poorly (AUC = 0.46). Removal of any of the core effectors caused a decrease in the model’s ability to predict sensitivity to TRAIL.