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Table 2 Selection of the 50 most relevant DE genes

From: RNA-seq analysis reveals significant transcriptome changes in turbot (Scophthalmus maximus) suffering severe enteromyxosis

Gene Short name Log-FC head kidney Log-FC spleen Log-FC pyloric caeca Category Associated function
MHC class I antigen MHC I -6.3 -4.9 -5.4 1 Antigen processing and presentation
Interferon regulatory factor 7 IFR7 -1.8 -1.6 -3.6 1 Positive regulation of interferons production
Interferon-induced protein 44 IFI44 -3.2 -3.6 -2.2 1 Interferon-inducible protein
Interferon-induced protein with tetratricopeptide repeats 1 IFIT-1 -4.7 -5.0 -2.1 1 Interferon-inducible protein
Gig2-like protein Gig2 -10.4 -12.8 -7.4 1 Interferon-inducible protein
Interferon gamma receptor alpha chain IFNGR1 -2.7 -4.4 -- 1 Regulation of interferon-gamma-mediated signalling pathway
Interferon regulatory factor 3 IFR3 -1.8 -2.1 -- 1 Positive regulation of interferons production
Toll-like receptor 9 TLR9 -3.0 -3.0 -- 1 Innate immune response; Positive regulation of interferons production
Mannose-binding lectin-associated serine protease-3b MASP3b 7.6 4.9 4.5 1 Complement activation
Epidermis-type lipoxygenase 3-like ALOXE3 5,7 6.8 10.3 1 Leukotriene metabolic process
L-amino-acid oxidase-like IL4I1 4.8 5.9 9.5 1 Innate immune response
Interleukin-17a f-1 IL-17A/F-1 -- -- -3.8 1 Inflammatory response
Interleukin-22 IL22 -4.5 -- -1.7 1 Inflammatory response
CD83 antigen CD83 -- -1.8 2.5 1 Defence response
CD209 antigen-like CD209 -- -4.3 2.2 1 Innate immune response
Cytochrome b-245 heavy chain CYBB -4.0 -- 3.7 1 Inflammatory response
CC chemokine CCL -- 1.9 4.0 1 Inflammatory response
Interleukin-1 receptor accessory protein IL1RAP -- -4.2 2.6 1 Inflammatory response
Lipopolysaccharide-induced tumor necrosis factor-alpha factor LITAF -- -1.6 6.2 1,2 Regulation of cytokine production-Apoptotic process
Immunoglobulin light chain IGlc -1.8 -2.0 2.7 1 Antigen binding
T-cell surface glycoprotein cd4 CD4 -- -1.6 -- 1 T cell receptor signalling pathway
T-cell receptor beta chain TCRB -- -2.0 -- 1 T cell receptor signalling pathway
Perforin-1-like PRF1 -3.2 -- -- 1 T cell-mediated cytolysis
Granzyme A/K GZM-A/K -1.7 -- -- 1 T cell-mediated cytolysis
Catalase CAT -2.0 -1.8 -2.5 1 Hydrogen peroxide catabolic process
Superoxide dismutase SOD -- -- -2.1 1 Removal of superoxide radicals
Glutathione s-transferase theta-1 GSTT1 -- -- -2.0 1 Oxidation-reduction process
Caspase-3-like CASP3 -- -- 5.5 2 Positive regulation of apoptotic process
Cytochrome c CYTC 2.5 -- 4.3 2 Apoptotic DNA fragmentation
TNF receptor-associated factor 2-like TRAF2 -- -- 3.6 2 Regulation of apoptotic process
Tumor necrosis factor receptor superfamily member 10b-like TNFRSF10B -3.2 -2.2 2.6 2 Regulation of apoptotic process
Hemoglobin subunit alpha-d HBAD -5.2 -3.5 -- 3 Oxygen transport
Hemoglobin subunit beta-2 HBB2 -4.7 -3.8 -- 3 Oxygen transport
Hemoglobin subunit beta-1 HBB1 -4.6 -3.2 -- 3 Oxygen transport
Band 3 anion exchange protein SLC4A1 -6.6 -4.5 -- 3 Erythrocytes differentiation
Gata-binding factor 2-like GATA2 -3.5 -2.2 -- 3 Erythrocytes differentiation
Mitoferrin-1 SLC25A37 -3.6 -3.5 -- 3 Erythrocytes maturation
T-cell acute lymphocytic leukemia protein 1 TAL1 -2,8 -1,6 -- 3 Erythrocytes differentiation- Erythrocytes maturation
Hepcidin HEPC 2.7 2.0 -- 3 Iron metabolism
Aminopeptidase n ANPEP 2.2 7.3 -9.2 4 Protein metabolic process
Intestinal-type alkaline phosphatase 1 ALPI -- -- -11.7 1,4 Metabolic process
Acidic mammalian chitinase CHIA -- -- -14.1 4 Carbohydrate metabolic process
Apolipoprotein a-iv precursor APOA4 -- -- -6.5 4 Lipoprotein metabolic process
Gastric inhibitory polypeptide GIP -- -- -3.1 4 Response to nutrient levels
Cocaine- and amphetamine-regulated transcript CART -- -- 6.7 4 Negative regulation of appetite
Gastrin cholecystokinin-like peptide GAST-CCK -- -- -4.4 4 Digestion
Collagen alpha-2 chain COL1A2 -2.0 -1.5 -2.4 5 Extracellular matrix structural constituent
Tropomodulin 4 TMOD4 -5.6 -3.9 -2.3 5 Tropomyosin binding
Formin-like protein 1-like FMNL1 -4.0 -3.0 -2.8 5 Actin cytoskeleton organization
Alpha actin ACTA -3.9 -- -2.7 5 Skeletal muscle fiber development
  1. Statistically significant fold changes are shown for each organ for 50 relevant genes associated with enteromyxosis. Categories: 1) Immune and defence response; 2) Apoptosis and cell proliferation; 3) Iron metabolism and erythropoiesis; 4) Metabolism and digestive function; 5) Cytoskeleton and extracellular matrix. Non significant differences have been marked as “--”.