Figure 4

Protein-protein interaction network for two PD map modules - glycolysis (A) and ROS metabolism (B). Red nodes refer to genes mutated in the cell line. Orange nodes refer to genes which are intact in the cell line. Nodes are scaled to the magnitude of their betweenness centralities. Blue edges show connections between pairs of nodes in which at least one was damaged in the cell line. For glycolysis, mutations in the central genes lead to the high BC-ratio. Mutated genes lie on the periphery of the ROS metabolism network resulting in a low BC-ratio.