Systems genomics evaluation of the SH-SY5Y neuroblastoma cell line as a model for Parkinson’s disease

BMC Genomics

Table 3 Network statistics and cell line scoring of the Parkinson’s disease modules

Module name	Nodes			Edges	Network centra-lization (Bet-weeness)	Cell line suitability based on centrality metrics				p_BC-value
Module name	Total	Damaged	Intact	Edges	Network centra-lization (Bet-weeness)	Degree	Closeness	BC-ratio	Flow BC	p_BC-value
Glycolysis	23	6	17	59	.321	.262	.256	.310	.253	.330
Mitochondria	259	32	227	4752	.127	.135	.137	.155	.128*	.297
Calcium signalling	125	17	108	561	.160	.163	.132	.149	.095*	.296
Apoptosis	122	15	107	250	.334	.080	.117	.146	.098*	.279
Dopamine	54	8	46	175	.030	.174	.179	.115	.224*	.448
Ubiquitin protease system	55	7	48	809	.070	.150	.153	.044	.133*	.340
ROS metabolism	58	3	55	121	.922	.012	.051	.000	.000	.375

Flow BC stands for flow betweenness centrality.The P_BC-value refers to the network randomization test described in the Methods section. Flow Betwenness is defined for connected networks. If the entire network is not connected, Flow betweenness is computed for connected components. In the table the flow betweenness centrality value of the largest connected component is given and marked by *.

ISSN: 1471-2164