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Table 3 Network statistics and cell line scoring of the Parkinson’s disease modules

From: Systems genomics evaluation of the SH-SY5Y neuroblastoma cell line as a model for Parkinson’s disease

Module name Nodes Edges Network centra-lization (Bet-weeness) Cell line suitability based on centrality metrics pBC-value
Total Damaged Intact Degree Closeness BC-ratio Flow BC
Glycolysis 23 6 17 59 .321 .262 .256 .310 .253 .330
Mitochondria 259 32 227 4752 .127 .135 .137 .155 .128* .297
Calcium signalling 125 17 108 561 .160 .163 .132 .149 .095* .296
Apoptosis 122 15 107 250 .334 .080 .117 .146 .098* .279
Dopamine 54 8 46 175 .030 .174 .179 .115 .224* .448
Ubiquitin protease system 55 7 48 809 .070 .150 .153 .044 .133* .340
ROS metabolism 58 3 55 121 .922 .012 .051 .000 .000 .375
  1. Flow BC stands for flow betweenness centrality.The PBC-value refers to the network randomization test described in the Methods section. Flow Betwenness is defined for connected networks. If the entire network is not connected, Flow betweenness is computed for connected components. In the table the flow betweenness centrality value of the largest connected component is given and marked by *.