Table 3 Upstream regulators with predicted Activation and Inhibition states distinguishing MERS-CoV Eng 1 and MERS-CoV SA 1 infections
Upstream regulator | p-value of overlap | MERS-CoV SA 1_18h | MERS-CoV Eng 1_18h | MERS-CoV SA 1_24h | MERS-CoV Eng 1_24h |
|---|---|---|---|---|---|
STAT3 | 3.82E-14 | -0.253 | 1.958 | 0.364 | 2.559 |
CTNNB1 | 1.20E-13 | -1.187 | 1.465 | -1.998 | 1.515 |
ESR1 | 1.82E-12 | 0.519 | -0.728 | -0.21 | -1.083 |
NFKBIA | 2.30E-10 | 0.604 | 1.108 | 0.635 | 1.477 |
NUPR1 | 2.40E-10 | -2.373 | 3.226 | -0.347 | 2.705 |
SP1 | 4.13E-10 | -2.222 | 2.021 | -1.62 | 0.831 |
NR3C1 | 5.66E-10 | -2.65 | -0.895 | -1.582 | -1.658 |
CREB1 | 1.86E-09 | -2.138 | 2.52 | -1.085 | 1.582 |
CEBPA | 3.63E-09 | 0.39 | -1.513 | 0.075 | -1.162 |
JUND | 3.71E-09 | 1.248 | 0.282 | 0.443 | -0.201 |
HIF1A | 1.32E-08 | -0.442 | 0.622 | -0.801 | 1.993 |
TP53 | 1.89E-08 | -1.46 | 0.719 | -1.608 | 1.228 |
AHR | 2.57E-08 | 1.482 | 1.642 | 0.227 | 0.984 |
FOS | 2.64E-08 | 0.188 | 0.188 | 0.188 | 1.076 |
FOXO3 | 2.76E-08 | 0.086 | 0.685 | -0.198 | -0.457 |
Histone h3 | 2.81E-08 | ||||
CEBPB | 6.11E-08 | 0.795 | -0.929 | -0.242 | 0.845 |
TP63 | 6.62E-08 | -0.084 | 1.834 | -0.557 | 0.605 |
NFKB1 | 1.35E-07 | -0.025 | 0.564 | 0.93 | 0.867 |
NFATC3 | 1.52E-07 | -1.082 | 0.8 | -0.687 | -0.286 |
PDX1 | 1.95E-07 | 1.223 | 1.206 | 1.077 | 1.673 |
SMARCA4 | 2.10E-07 | -1.283 | 0.435 | -0.377 | 1.115 |
EGR1 | 2.16E-07 | 0.38 | 1.407 | -0.626 | 0.464 |
Ap1 | 5.52E-07 | ||||
CREM | 6.36E-07 | -0.951 | 1.412 | -0.254 | 2.437 |
FOXL2 | 6.57E-07 | 1.267 | 2.428 | 0.682 | 3.559 |