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Table 3 Upstream regulators with predicted Activation and Inhibition states distinguishing MERS-CoV Eng 1 and MERS-CoV SA 1 infections

From: Cytokine systems approach demonstrates differences in innate and pro-inflammatory host responses between genetically distinct MERS-CoV isolates

Upstream regulator p-value of overlap MERS-CoV SA 1_18h MERS-CoV Eng 1_18h MERS-CoV SA 1_24h MERS-CoV Eng 1_24h
STAT3 3.82E-14 -0.253 1.958 0.364 2.559
CTNNB1 1.20E-13 -1.187 1.465 -1.998 1.515
ESR1 1.82E-12 0.519 -0.728 -0.21 -1.083
NFKBIA 2.30E-10 0.604 1.108 0.635 1.477
NUPR1 2.40E-10 -2.373 3.226 -0.347 2.705
SP1 4.13E-10 -2.222 2.021 -1.62 0.831
NR3C1 5.66E-10 -2.65 -0.895 -1.582 -1.658
CREB1 1.86E-09 -2.138 2.52 -1.085 1.582
CEBPA 3.63E-09 0.39 -1.513 0.075 -1.162
JUND 3.71E-09 1.248 0.282 0.443 -0.201
HIF1A 1.32E-08 -0.442 0.622 -0.801 1.993
TP53 1.89E-08 -1.46 0.719 -1.608 1.228
AHR 2.57E-08 1.482 1.642 0.227 0.984
FOS 2.64E-08 0.188 0.188 0.188 1.076
FOXO3 2.76E-08 0.086 0.685 -0.198 -0.457
Histone h3 2.81E-08     
CEBPB 6.11E-08 0.795 -0.929 -0.242 0.845
TP63 6.62E-08 -0.084 1.834 -0.557 0.605
NFKB1 1.35E-07 -0.025 0.564 0.93 0.867
NFATC3 1.52E-07 -1.082 0.8 -0.687 -0.286
PDX1 1.95E-07 1.223 1.206 1.077 1.673
SMARCA4 2.10E-07 -1.283 0.435 -0.377 1.115
EGR1 2.16E-07 0.38 1.407 -0.626 0.464
Ap1 5.52E-07     
CREM 6.36E-07 -0.951 1.412 -0.254 2.437
FOXL2 6.57E-07 1.267 2.428 0.682 3.559
  1. Ingenuity Pathway Analysis was used to determine the top 20 Upstream Regulators. z-scores for predicted upstream regulators (|z| >2) at each time point are shown. z >2 predicts activation of the upstream regulator. z < -2 predicts inhibition of the upstream regulator. The Activation z-score was used to rank the Upstream Regulator based on the “Inhibited” status (darker cells indicated more significant “Inhibited” status of Upstream Regulator).
  2. Upstream Regulators in bold indicates enrichment of DNA-binding motifs (human) via TRANSFAC promoter analysis intersected DE genesets for MERS-CoV Eng 1 and MERS-CoV SA 1 at either 18 or 24 hpi (q-value of 10-7).