Analysis of the core and pan-genome of A. baumannii isolates. (A) Core and pan-genomic calculations in A. baumannii isolates. Each green point represents the number of genes conserved between genomes. All of the points are plotted as a function of the strain number (x). The deduced pan-genome size: P(x) = 972×0.54 + 2786.22. The height of the curve continues to increase because the pan-genome of A. baumannii is open. (B). Genes missing or present in A. baumannii isolates. The heat map illustrates the distribution of core and accessory genes across the A. baumannii strains. The columns represent A. baumannii isolates. The rows represent genes. The red and black regions represent the presence or absence of genes in a particular genome, respectively. The black regions indicate features missing in that strain but present in one or more of the other A. baumannii strains. (C). The distribution of all, core, and specific genes according to the COG classification. The y-axis indicates the percentage of genes in various COG categories. (U) Intracellular trafficking and secretion; (V) Defense mechanisms; (D) Cell cycle control, mitosis, and meiosis; (F) Nucleotide transport and metabolism; (O) Post-translational modification, protein turnover, chaperones; (O) Posttranslational modification, protein turnover, chaperones; (J) Translation, ribosomal structure and biogenesis; (H) Coenzyme transport and metabolism; (M) Cell wall/membrane/envelope biogenesis; (S) Function unknown; (K) Transcription; (P) Inorganic ion transport and metabolism; (T) Signal transduction mechanisms; (G) Carbohydrate transport and metabolism; (N) Cell motility; (C) Energy production and conversion; (L) Replication, recombination, and repair; (E) Amino acid transport and metabolism; (I) Lipid transport and metabolism; (R) General function prediction only; (Q) Secondary metabolites biosynthesis, transport, and catabolism.