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Table 4 Antimicrobial resistance-associated genes in the 8 BJ strains and 16 reference strains. 0 = absent, 1 = present, 1R = present and resistant (bearing a point mutation), 1S = present but sensitive (no point mutation)

From: Comparative genomic analysis of Acinetobacter baumannii clinical isolates reveals extensive genomic variation and diverse antibiotic resistance determinants

Drug class Enzyme class, description Coding gene BJ1 BJ2 BJ3 BJ4 BJ5 BJ6 BJ7 BJ8 AYE ACICU TYTH-1 AB0715 1656-2 ZW85-1 D1279779 AB0057 AB307-0294 ATCC17978 MDR-TJ MDR-ZJ06 BJAB07104 BJAB0868 BJAB0715 SDF
β-Lactamases class A β-lactamase tem-1 1 1 0 0 1 1 1 1 0 0 0 1 0 0 0 1 0 0 0 0 0 1 0 0
per-1 0 0 0 0 0 0 0 1 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0
veb 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
putative class A β-lactamase   1 1 1 0 1 1 1 1 0 1 1 1 1 0 0 1 0 1 1 1 1 1 1 0
class C β-lactamase ampC 1 1 1 1 1 2 1 1 1 3 1 2 2 0 1 2 1 1 4 2 3 3 2 0
putative class C β-lactamase   1 1 1 1 1 0 1 1 0 0 1 0 0 0 0 0 0 0 0 0 0 0 1 0
class D β-lactamase bla OXA-23 1 1 1 0 1 1 1 0 0 0 0 1 0 0 0 1 0 0 1 1 1 1 1 0
bla OXA-66 1 1 1 0 1 1 1 1 0 1 0 1 0 0 0 0 0 0 1 1 1 1 0 0
bla OXA-69 0 0 0 1 0 0 0 0 1 0 0 0 0 0 0 1 1 0 0 0 0 0 0 0
bla OXA-10 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0
  bla OXA-90 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0
  bla OXA-109 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0
metallo-β-lactamase superfamily   2 2 1 1 2 2 2 2 1 1 0 2 0 4 5 5 7 1 2 1 1 1 0 0
Aminoglycosides aminoglycoside N-acetyltransferase aacA4 0 0 1 0 1 0 0 0 0 1 1 1 0 0 0 0 0 0 1 1 1 1 0 0
aacC1 1 1 0 0 0 1 1 0 1 0 0 1 1 0 0 1 0 0 1 1 0 0 0 0
aac3iia 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0
aminoglycoside O-phosphotransferase strA 0 1 1 0 0 1 1 1 1 0 1 1 2 0 0 0 0 0 1 1 1 1 1 0
strB 0 1 1 0 0 1 1 1 1 0 1 1 1 0 0 0 0 0 1 1 1 1 1 0
aphA1 0 1 1 1 0 1 1 1 2 1 1 3 1 1 1 2 1 0 1 2 2 2 0 1
aph3via 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 1 0
  aminoglycoside O-adenylyltransferase aadA1 1 1 1 0 1 1 1 0 2 0 1 2 2 0 0 1 0 0 2 2 1 1 0 0
ant2ia 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Chloramphenicol group A chloramphenicol acetyltransferase catA1 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0
group B chloramphenicol acetyltransferase catB8 0 0 1 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0
catB3 0 0 0 0 0 0 0 0 0 0 1 1 0 0 0 0 0 0 1 1 1 1 0 0
Sulfonamides sulfonamide-resistant dihydropteroate synthase sul1 1 1 1 0 1 1 1 1 3 1 1 2 1 0 0 2 0 0 2 2 1 1 0 0
sul2 0 1 1 0 0 0 0 1 0 0 1 1 1 1 0 0 0 1 1 0 1 1 1 0
Fluoroquinolones gyrA mutation (Ser-83 → Leu) gyrA 1R 1R 1R 1S 1R 1R 1R 1R 1R 1R 1R 1R 1R 1S 1S 1R 1R 1S 1R 1R 1R 1R 1R 1S
parC mutation (Ser-80 → Ile) parC 1R 1R 1R 1S 1R 1R 1R 1S 1R 1S 1S 1R 1S 1S 1S 1R 1S 1S 1S 1S 1S 1S 1S 1S
Efflux pumps MFS (major facilitator superfamily) family tetA 0 1 1 0 0 1 1 0 1 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0
tetB 0 0 0 0 0 0 0 0 0 0 1 1 0 1 0 0 0 0 1 1 1 1 1 0
tetG 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
cmlA 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
cmlA5 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
RND (resistance-nodulation-division) family adeA 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 0 0
adeB 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 0 0
adeC 1 1 1 1 1 1 1 1 1 1 1 1 1 0 0 1 1 0 1 1 1 1 0 0