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Table 1 Differentially expressed muscle proteins in total extract between adult (56 yr) and old (78 yr) post-menauposal women

From: Proteomics of muscle chronological ageing in post-menopausal women

2DGE pH Spot n° Accession Symbol Protein name Fold change Age effect (pvalue) Mascot score Sequence coverage (%) Unique peptides Main biological function
5-8 1882 P05976 MYL1 Myosin light chain 1/3 +1.4 0.020 693 41 5 Myofilaments and cytoskeleton
5-8 2032 P10916 MYL2 Myosin regulatory light chain 2 −1.7 0.012 4807 86 15 Myofilaments and cytoskeleton
5-8 1123 P45378 TNNT3 Troponin T, fast skeletal muscle +1.9 0.033 288 24 4 Myofilaments and cytoskeleton
5-8 1333 P68133 ACTA1 Actin, alpha skeletal muscle (N-term fragment) +1.7 0.042 999 23 4 Myofilaments and cytoskeleton
5-8 1415 P68133 ACTA1 Actin, alpha skeletal muscle (N-term fragment) +1.3 0.034 847 29 4 Myofilaments and cytoskeleton
5-8 1417 P68133 ACTA1 Actin, alpha skeletal muscle (C-term fragment) +1.3 0.041 350 19 4 Myofilaments and cytoskeleton
5-8 570 P12882 MYH1 Myosin-1 (C-term fragment) +2.3 0.011 712 9 11 Myofilaments and cytoskeleton
3-5.6 665 P31415 CASQ1 Calsequestrin-1 +1.4 0.045 1146 22 9 Signal transduction
5-8 858 Q86TD4 SRL Sarcalumenin (mature C-term) −1.6 0.008 1606 44 17 Signal transduction
5-8 3260 Q9NP98 MYOZ1 Myozenin-1 +1.7 0.008 435 22 4 Signal transduction
3-5.6 758 P20073 ANXA7 Annexin A7 +1.8 0.029 954 15 6 Signal transduction, autophagy
5-8 300 P06732 CKM Creatine kinase M-type (dimer) −1.7 0.031 445 25 7 Energy metabolism
5-8 332 P06732 CKM Creatine kinase M-type (dimer) −1.7 0.048 737 39 11 Energy metabolism
5-8 391 P11217 PYGM Glycogen phosphorylase, muscle form −2.6 0.031 1516 39 23 Energy metabolism, glycogenolysis
5.3-6.5 1874 P21695 GPD1 Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic −1.4 0.040 3383 53 17 Energy metabolism, shuttle
5-8 3459 Q8N335 GPD1L Glycerol-3-phosphate dehydrogenase 1-like protein −1.4 0.022 1884 55 14 Energy metabolism, shuttle, hypoxia
5-8 3511 P60174 TPI1 Triosephosphate isomerase +1.3 0.050 798 56 9 Energy metabolism, glycolysis, detoxification
5-8 1196 P11177 PDHB Pyruvate dehydrogenase E1 component subunit beta −1.3 0.043 2267 59 14 Energy metabolism, Krebs cycle
5-8 769 P09622 DLD Dihydrolipoyl dehydrogenase, mitochondrial −1.4 0.010 466 29 8 Energy metabolism, Krebs cycle
5-8 577 Q99798 ACO2 Aconitate hydratase, mitochondrial −1.6 0.043 365 19 9 Energy metabolism, Krebs cycle
5-8 984 O75306 NDUFS2 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial −1.6 0.005 1777 49 15 Energy metabolism, oxidative phosphorylation
5-8 3417 P47985 UQCRFS1 Cytochrome b-c1 complex subunit Rieske, mitochondrial −1.3 0.031 1271 23 5 Energy metabolism, oxidative phosphorylation
3-5.6 2713 P20674 COX5A Cytochrome c oxidase subunit 5A, mitochondrial −1.5 0.015 779 48 6 Energy metabolism, oxidative phosphorylation
5-8 909 P06576 ATP5B ATP synthase subunit beta −1.4 0.023 2725 62 20 Energy metabolism, oxidative phosphorylation
5-8 2371 P05413 FABP3 Fatty acid-binding protein, heart −1.4 0.004 2281 77 11 Energy metabolism, lipid transport
5-8 3328 P15121 AKR1B1 Aldose reductase −1.5 0.016 323 31 5 Detoxification, cytoprotection
3-5.6 1414 P04792 HSPB1 Heat shock protein beta-1 +1.7 0.019 714 36 5 Detoxification, cytoprotection
5.3-6.5 2375 P04792 HSPB1 Heat shock protein beta-1 +1.3 0.026 484 41 6 Detoxification, cytoprotection
5-8 678 P08107 HSPA1A Heat shock 70 kDa protein 1A/1B +1.1 0.014 3630 52 14 Detoxification, cytoprotection
5-8 3332 P38646 HSPA9 Stress-70 protein, mitochondrial +1.4 0.008 5401 45 22 Detoxification, cytoprotection
5-8 3289 P00918 CA2 Carbonic anhydrase 2 +1.3 0.047 1605 54 11 Detoxification, cytoprotection
5-8 877 Q13228 SELENBP1 Selenium-binding protein 1 −1.5 0.028 1677 56 19 Detoxification, cytoprotection
5.3-6.5 2410 P28070 PSMB4 Proteasome subunit beta type-4 −1.4 0.049 1692 33 5 Proteolysis
3-5.6 3387 P54725 RAD23A UV excision repair protein RAD23 homolog A −1.3 0.041 309 28 6 Proteolysis
5-8 3270 P49411 TUFM Elongation factor Tu, mitochondrial −1.4 0.001 1548 38 12 Protein synthesis, proteolysis
5-8 919 P02679 FGG Fibrinogen gamma chain −1.3 0.026 1023 59 16 Serum
5-8 1429 P30042 C21orf33 ES1 protein homolog, mitochondrial −1.6 0.001 364 51 6 Miscellaneous
5-8 1430 P30042 C21orf33 ES1 protein homolog, mitochondrial −1.7 0.002 118 18 3 Miscellaneous
5-8 1177 Q9H0P0 NT5C3 Cytosolic 5'-nucleotidase 3 −1.6 0.015 589 35 10 Miscellaneous
3-5.6 1429 Q9Y235 APOBEC2 Apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 2 −1.2 0.018 1904 74 11 Miscellaneous