Proteomics of muscle chronological ageing in post-menopausal women

Gueugneau, Marine; Coudy-Gandilhon, Cécile; Gourbeyre, Ophélie; Chambon, Christophe; Combaret, Lydie; Polge, Cécile; Taillandier, Daniel; Attaix, Didier; Friguet, Bertrand; Maier, Andrea B; Butler-Browne, Gillian; Béchet, Daniel

doi:10.1186/1471-2164-15-1165

BMC Genomics

Table 2 Differentially expressed muscle proteins in low ionic strength (LIS) extract between adult (56 yr) and old (78 yr) post-menauposal women

From: Proteomics of muscle chronological ageing in post-menopausal women

Spot n°	Accession	Symbol	Protein name	Fold change	Age effect (pvalue)	Mascot score	Sequence coverage (%)	Unique peptides	Main biological function
1734	E7ENC6	TTN	Titin (C-term fragment)	−1.4	0.032	4511	1	11	Myofilaments and cytoskeleton
1361	Q9GZV1	ANKRD2	Ankyrin repeat domain-containing protein 2	+1.8	0.033	1831	51	14	Myofilaments and cytoskeleton
522	P18206-2	VCL	Vinculin, isoform 1	+1.5	0.048	1457	21	17	Myofilaments and cytoskeleton
526	P18206-2	VCL	Vinculin, isoform 1	+1.6	0.026	1329	26	20	Myofilaments and cytoskeleton
1418	Q13643	FHL3	Four and a half LIM domains protein 3	−1.5	0.038	1046	42	8	Myofilaments and cytoskeleton
1179	P10644	PRKAR1A	cAMP-dependent protein kinase type I-alpha regulatory subunit	+1.6	0.021	903	37	11	Signal transduction
1494	P04083	ANXA1	Annexin A1	+1.3	0.049	4205	59	17	Signal transduction, dystrophies
1619	P08758	ANXA5	Annexin A5	+1.5	0.005	3264	64	16	Signal transduction, membrane repair
1673	P78417	GSTO1	Glutathione S-transferase omega-1	−1.5	0.049	674	44	7	Detoxification, signal transduction
1261	P06732	CKM	Creatine kinase M-type	−1.3	0.019	3974	45	15	Energy metabolism
1266	P06732	CKM	Creatine kinase M-type	−1.2	0.044	6576	50	16	Energy metabolism
1276	P06732	CKM	Creatine kinase M-type	−1.2	0.017	8749	57	17	Energy metabolism
1289	P06732	CKM	Creatine kinase M-type	−1.1	0.044	10394	52	17	Energy metabolism
3617	P06732	CKM	Creatine kinase M-type	−1.4	0.037	3259	43	13	Energy metabolism
516	P06732	CKM	Creatine kinase M-type (trimer)	−1.2	0.022	5360	54	16	Energy metabolism
289	P11217	PYGM	Glycogen phosphorylase, muscle form	+1.4	0.019	3091	48	28	Energy metabolism, glycogenolysis
659	F5GZH7	PYGM	Phosphorylase	+1.3	0.027	4260	49	31	Energy metabolism, glycogenolysis
676	F5GZH7	PYGM	Phosphorylase	+1.7	0.004	662	24	12	Energy metabolism, glycogenolysis
696	F5GZH7	PYGM	Phosphorylase	+1.5	0.004	917	23	15	Energy metabolism, glycogenolysis
998	P36871	PGM1	Phosphoglucomutase-1	−1.3	0.017	1772	33	14	Energy metabolism, glycogenolysis
1209	P13929	ENO3	Beta-enolase	−1.3	0.005	3382	41	12	Energy metabolism, glycolysis
1210	P13929	ENO1/3	Alpha/beta-enolase	−1.7	0.027	5218	53	12	Energy metabolism, glycolysis
1213	P13929	ENO3	Beta-enolase	−1.3	0.044	9731	62	20	Energy metabolism, glycolysis
1215	P13929	ENO3	Beta-enolase	−1.6	0.014	3548	49	13	Energy metabolism, glycolysis
1236	P13929	ENO3	Beta-enolase	−1.2	0.011	12846	62	22	Energy metabolism, glycolysis
1448	P07195	LDHB	L-lactate dehydrogenase B chain	−1.3	0.043	2156	46	11	Energy metabolism, glycolysis
1229	P07954-2	FH	Fumarate hydratase	−1.4	0.010	2328	44	12	Energy metabolism, Krebs cycle
3215	P15090	FABP4	Fatty acid-binding protein, adipocyte	+1.5	0.038	4748	70	10	Energy metabolism, lipid, ER stress
1007	P04040	CAT	Catalase	−1.3	0.026	654	21	9	Detoxification, cytoprotection
1754	E9PH29	PRDX3	Thioredoxin-dependent peroxide reductase, mitochondrial	+1.5	0.012	1802	47	9	Detoxification, cytoprotection
1858	Q99497	PARK7	Protein DJ-1	+1.2	0.043	334	42	6	Detoxification, cytoprotection
1107	P05091	ALDH2	Aldehyde dehydrogenase	+1.2	0.012	7985	48	19	Detoxification, cytoprotection
1351	P14550	AKR1A1	Alcohol dehydrogenase	+1.4	0.006	1387	46	13	Detoxification, cytoprotection
1011	P30038	ALDH4A1	Delta-1-pyrroline-5-carboxylate dehydrogenase	−1.2	0.027	1219	21	9	Amino acid metabolism
1762	P04792	HSPB1	Heat shock protein beta-1	+1.3	0.027	1453	51	7	Detoxification, cytoprotection
1763	P04792	HSPB1	Heat shock protein beta-1	+1.3	0.029	1286	51	8	Detoxification, cytoprotection
2356	E9PR44	HSPB5	Alpha-crystallin B chain	+1.5	0.038	1046	39	6	Detoxification, cytoprotection
2364	O14558	HSPB6	Heat shock protein beta-6	+1.2	0.043	597	71	4	Detoxification, cytoprotection
755	P08238	HSPC2/3	Heat shock protein HSP 90-alpha/beta	+1.9	0.035	3256	38	12	Detoxification, cytoprotection
1081	B3KQT9	PDIA3	Protein disulfide-isomerase A3	+1.4	0.012	965	36	15	Detoxification, cytoprotection
812	P00918	CA2	Carbonic anhydrase 2	+1.2	0.038	3352	72	15	Detoxification, cytoprotection
1752	P07451	CA3	Carbonic anhydrase 3	+1.2	0.004	3663	58	11	Detoxification, cytoprotection
1755	P07451	CA3	Carbonic anhydrase 3	+1.2	0.025	6098	72	14	Detoxification, cytoprotection
1119	Q13228	SELENBP1	Selenium-binding protein 1	+1.2	0.006	4100	70	23	Detoxification, cytoprotection
1127	Q13228	SELENBP1	Selenium-binding protein 1	+1.2	0.036	3543	63	21	Detoxification, cytoprotection
3614	P22314	UBA1	Ubiquitin-like modifier-activating enzyme 1	+1.8	0.033	7675	42	29	Proteolysis
3654	P55072	VCP	Transitional endoplasmic reticulum ATPase	+1.5	0.011	1920	39	23	Proteolysis
1088	P12955	PEPD	Xaa-Pro dipeptidase	+1.4	0.021	948	24	9	Proteolysis
1014	P01008	SERPINC1	Antithrombin-III	−1.2	0.014	3612	44	18	Proteolysis
1070	P02774	GC	Vitamin D-binding protein	−1.4	0.008	2704	40	14	Serum
2892	P02766	TTR	Transthyretin	−1.3	0.026	3695	65	8	Serum
1847	P02647	APOA1	Apolipoprotein A-I	−1.5	0.002	5385	55	15	Serum
1855	P02647	APOA1	Apolipoprotein A-I	−1.5	0.004	8189	54	15	Serum
3624	P02647	APOA1	Apolipoprotein A-I	−1.3	0.042	1347	41	8	Serum
681	P02787	TF	Serotransferrin	+1.7	0.047	1523	38	16	Serum

Back to article page

ISSN: 1471-2164

Contact us

Submission enquiries: bmcgenomics@biomedcentral.com
General enquiries: ORSupport@springernature.com