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Table 2 Differentially expressed muscle proteins in low ionic strength (LIS) extract between adult (56 yr) and old (78 yr) post-menauposal women

From: Proteomics of muscle chronological ageing in post-menopausal women

Spot n° Accession Symbol Protein name Fold change Age effect (pvalue) Mascot score Sequence coverage (%) Unique peptides Main biological function
1734 E7ENC6 TTN Titin (C-term fragment) −1.4 0.032 4511 1 11 Myofilaments and cytoskeleton
1361 Q9GZV1 ANKRD2 Ankyrin repeat domain-containing protein 2 +1.8 0.033 1831 51 14 Myofilaments and cytoskeleton
522 P18206-2 VCL Vinculin, isoform 1 +1.5 0.048 1457 21 17 Myofilaments and cytoskeleton
526 P18206-2 VCL Vinculin, isoform 1 +1.6 0.026 1329 26 20 Myofilaments and cytoskeleton
1418 Q13643 FHL3 Four and a half LIM domains protein 3 −1.5 0.038 1046 42 8 Myofilaments and cytoskeleton
1179 P10644 PRKAR1A cAMP-dependent protein kinase type I-alpha regulatory subunit +1.6 0.021 903 37 11 Signal transduction
1494 P04083 ANXA1 Annexin A1 +1.3 0.049 4205 59 17 Signal transduction, dystrophies
1619 P08758 ANXA5 Annexin A5 +1.5 0.005 3264 64 16 Signal transduction, membrane repair
1673 P78417 GSTO1 Glutathione S-transferase omega-1 −1.5 0.049 674 44 7 Detoxification, signal transduction
1261 P06732 CKM Creatine kinase M-type −1.3 0.019 3974 45 15 Energy metabolism
1266 P06732 CKM Creatine kinase M-type −1.2 0.044 6576 50 16 Energy metabolism
1276 P06732 CKM Creatine kinase M-type −1.2 0.017 8749 57 17 Energy metabolism
1289 P06732 CKM Creatine kinase M-type −1.1 0.044 10394 52 17 Energy metabolism
3617 P06732 CKM Creatine kinase M-type −1.4 0.037 3259 43 13 Energy metabolism
516 P06732 CKM Creatine kinase M-type (trimer) −1.2 0.022 5360 54 16 Energy metabolism
289 P11217 PYGM Glycogen phosphorylase, muscle form +1.4 0.019 3091 48 28 Energy metabolism, glycogenolysis
659 F5GZH7 PYGM Phosphorylase +1.3 0.027 4260 49 31 Energy metabolism, glycogenolysis
676 F5GZH7 PYGM Phosphorylase +1.7 0.004 662 24 12 Energy metabolism, glycogenolysis
696 F5GZH7 PYGM Phosphorylase +1.5 0.004 917 23 15 Energy metabolism, glycogenolysis
998 P36871 PGM1 Phosphoglucomutase-1 −1.3 0.017 1772 33 14 Energy metabolism, glycogenolysis
1209 P13929 ENO3 Beta-enolase −1.3 0.005 3382 41 12 Energy metabolism, glycolysis
1210 P13929 ENO1/3 Alpha/beta-enolase −1.7 0.027 5218 53 12 Energy metabolism, glycolysis
1213 P13929 ENO3 Beta-enolase −1.3 0.044 9731 62 20 Energy metabolism, glycolysis
1215 P13929 ENO3 Beta-enolase −1.6 0.014 3548 49 13 Energy metabolism, glycolysis
1236 P13929 ENO3 Beta-enolase −1.2 0.011 12846 62 22 Energy metabolism, glycolysis
1448 P07195 LDHB L-lactate dehydrogenase B chain −1.3 0.043 2156 46 11 Energy metabolism, glycolysis
1229 P07954-2 FH Fumarate hydratase −1.4 0.010 2328 44 12 Energy metabolism, Krebs cycle
3215 P15090 FABP4 Fatty acid-binding protein, adipocyte +1.5 0.038 4748 70 10 Energy metabolism, lipid, ER stress
1007 P04040 CAT Catalase −1.3 0.026 654 21 9 Detoxification, cytoprotection
1754 E9PH29 PRDX3 Thioredoxin-dependent peroxide reductase, mitochondrial +1.5 0.012 1802 47 9 Detoxification, cytoprotection
1858 Q99497 PARK7 Protein DJ-1 +1.2 0.043 334 42 6 Detoxification, cytoprotection
1107 P05091 ALDH2 Aldehyde dehydrogenase +1.2 0.012 7985 48 19 Detoxification, cytoprotection
1351 P14550 AKR1A1 Alcohol dehydrogenase +1.4 0.006 1387 46 13 Detoxification, cytoprotection
1011 P30038 ALDH4A1 Delta-1-pyrroline-5-carboxylate dehydrogenase −1.2 0.027 1219 21 9 Amino acid metabolism
1762 P04792 HSPB1 Heat shock protein beta-1 +1.3 0.027 1453 51 7 Detoxification, cytoprotection
1763 P04792 HSPB1 Heat shock protein beta-1 +1.3 0.029 1286 51 8 Detoxification, cytoprotection
2356 E9PR44 HSPB5 Alpha-crystallin B chain +1.5 0.038 1046 39 6 Detoxification, cytoprotection
2364 O14558 HSPB6 Heat shock protein beta-6 +1.2 0.043 597 71 4 Detoxification, cytoprotection
755 P08238 HSPC2/3 Heat shock protein HSP 90-alpha/beta +1.9 0.035 3256 38 12 Detoxification, cytoprotection
1081 B3KQT9 PDIA3 Protein disulfide-isomerase A3 +1.4 0.012 965 36 15 Detoxification, cytoprotection
812 P00918 CA2 Carbonic anhydrase 2 +1.2 0.038 3352 72 15 Detoxification, cytoprotection
1752 P07451 CA3 Carbonic anhydrase 3 +1.2 0.004 3663 58 11 Detoxification, cytoprotection
1755 P07451 CA3 Carbonic anhydrase 3 +1.2 0.025 6098 72 14 Detoxification, cytoprotection
1119 Q13228 SELENBP1 Selenium-binding protein 1 +1.2 0.006 4100 70 23 Detoxification, cytoprotection
1127 Q13228 SELENBP1 Selenium-binding protein 1 +1.2 0.036 3543 63 21 Detoxification, cytoprotection
3614 P22314 UBA1 Ubiquitin-like modifier-activating enzyme 1 +1.8 0.033 7675 42 29 Proteolysis
3654 P55072 VCP Transitional endoplasmic reticulum ATPase +1.5 0.011 1920 39 23 Proteolysis
1088 P12955 PEPD Xaa-Pro dipeptidase +1.4 0.021 948 24 9 Proteolysis
1014 P01008 SERPINC1 Antithrombin-III −1.2 0.014 3612 44 18 Proteolysis
1070 P02774 GC Vitamin D-binding protein −1.4 0.008 2704 40 14 Serum
2892 P02766 TTR Transthyretin −1.3 0.026 3695 65 8 Serum
1847 P02647 APOA1 Apolipoprotein A-I −1.5 0.002 5385 55 15 Serum
1855 P02647 APOA1 Apolipoprotein A-I −1.5 0.004 8189 54 15 Serum
3624 P02647 APOA1 Apolipoprotein A-I −1.3 0.042 1347 41 8 Serum
681 P02787 TF Serotransferrin +1.7 0.047 1523 38 16 Serum
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