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Figure 6 | BMC Genomics

Figure 6

From: The translation initiation complex eIF3 in trypanosomatids and other pathogenic excavates – identification of conserved and divergent features based on orthologue analysis

Figure 6

Evolutionary relationship of selected eIF3i orthologues and conservation of the its eIF3b and eIF3g interacting elements. A Maximum Likelihood tree based on the alignment of several eIF3i orthologues plus WD containing proteins from various protozoan and multicellular eukaryotes. B Schematic representation of T. brucei EIF3I. The position of the segment implicated in the binding to eIF3b [44] is indicated by a blue box. C Amino acid sequence alignment comparing the C-terminal half of eIF3i orthologues from the organisms selected for this study. The alignment was carried out as described for the previous figures. Residues seen to be involved in the interaction of eIF3i with eIF3b in yeast [44] are indicated by the “+” symbol, whilst residues which, when mutated, interfered in the interaction with eIF3g [43] are marked with “#”.

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BMC Genomics

ISSN: 1471-2164

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