The distribution of DNA methylation with respect to CpG islands and gene structures. A-K) The density (y-axis) of probes at each methylation level (x-axis; beta) in human brain samples that were either interrogated for total methylation (5mc + 5hmc (black line)) or 5-hmC levels (5hmc (blue line)). A-E) Profiles shown are delineated for the island, the island shores (N_shore (5’ end) and S_shore (3’ end)) or the island shelves (N_Shelf and S_Shelf, which are defined as 0-2 or 2-4 kilobases flanking the island, respectively. F-I) Profiles shown are delineated relative to a gene, including the distance to the gene transcription start site (TSS; TSS1500 (i.e. within 1500 bp of the TSS) and TSS200), 5’UTR, 1st exon, body, and 3’UTR. The number of probes is indicated for each island and gene category.