Table 2 List of consistently up- and downregulated transcripts (cut off 1.4 fold change)
From: Unique features of the transcriptional response to model aneuploidy in human cells
Gene | Chromosome | Function | Protein levels | Link to cancer? | |
|---|---|---|---|---|---|
1 | PLAUR | 19 | Plasminogen activator, urokinase receptor | 4/5 | Ovarian and colorectal cancer |
2 | RAB27B | 18 | Secretory GTPase | 4/4 | Breast cancer |
3 | P4HA2 | 5 | Procollagen-proline | 4/6 | Metastasis |
4 | FRY | 13 | Regulator of actin cytoskeleton | 0/3 | |
5 | BDKRB1 | 14 | Bradykinine receptor | NA | Breast and lung cancer |
6 | HOXB5 | 17 | Transcription factor | NA | Leukemia, ovarian carcinoma and others |
7 | GDF15 | 19 | Growth differentiation factor | 1/2 | Ovarian and prostate cancer |
8 | OASL | 12 | 2'-5'-oligoadenylate synthetase-like | NA | |
9 | SERPINE2 | 2 | Serpine protease inhibitor | 4/4 | Metastasis |
10 | IFI44 | 1 | Interferon-induced protein 44 | NA | |
11 | AMDHD1 | 12 | Protein with amidohydrolase domain | NA | |
12 | TMEM171 | 5 | Transmembrane protein 171 | NA | |
13 | GLRX | 5 | Glutaredoxin | 4/4 | Pancreatic cancer |
14 | TMEM169 | 2 | Transmembrane protein 169 | NA | |
15 | DMBT1 | 10 | Membrane glycoprotein | NA | Multiple cancers |
16 | COL13A1 | 10 | Collagen type XIII, alpha1 | 1/1 | |
17 | SH2D1B | 1 | Signal transduction control | NA | |
18 | MIA | Melanoma inhibitory activity | NA | Neuronal tumors | |
1 | XYLB | 3 | Xylulokinase homologue | NA | |
2 | LOXL3 | 2 | Lysyl oxidase homologue | NA | |
3 | MYB/NFIB fusion | 6 | Myb – NFIB fusion | NA | |
4 | EEPD | 7 | Endonuclease/exonuclease/phosphatase domain containing | NA | |
5 | ARHGEF39 | 9 | Rho guanine nucleotide exchange factor 39 | NA |