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Table 2 Unadjusted (raw) and corrected p -values for the 25 top-ranking SNPs from the genome-wide Cochran-Mantel-Haenszel (CMH) association analysis

From: A genome-wide association study demonstrates significant genetic variation for fracture risk in Thoroughbred racehorses

CHR SNP BP POSN RISK ALLELE FREQ CASES FREQ CONTROLS χ2 Punadjusted OR SE Pcorrected
1 BIEC2-6883 14167279 G 0.389 0.274 21.44 3.66 × 10 -6 1.99 0.153 0.044
1 BIEC2-21406 50074740 G 0.878 0.821 14.60 1.33 × 10-4 2.13 0.197 0.868
1 BIEC2-85595 176967404 T 0.781 0.696 15.75 7.24 × 10-5 1.82 0.156 0.694
3 BIEC2-792745 73658246 T 0.955 0.911 16.16 5.82 × 10-5 3.20 0.298 0.608
3 BIEC2-793836 76584425 G 0.671 0.522 17.45 2.95 × 10-5 1.82 0.145 0.389
8 BIEC2-1062740 73825113 G 0.732 0.650 15.78 7.11 × 10-5 1.84 0.154 0.689
9 BIEC2-1094991 53231490 G 0.934 0.874 19.94 7.99 × 10-6 2.88 0.250 0.126
15 BIEC2-316813 68450494 A 0.937 0.864 20.15 7.17 × 10-6 2.99 0.256 0.111
18 BIEC2-438205 62035484 C 0.257 0.157 16.88 3.98 × 10-5 2.13 0.186 0.484
18 BIEC2-416680 62049912 G 0.263 0.144 22.79 1.81 × 10 -6 2.33 0.179 0.027
18 BIEC2-416681 62054146 A 0.265 0.144 23.74 1.10 × 10 -6 2.38 0.180 0.018
18 BIEC2-438210 62054710 C 0.255 0.157 17.02 3.70 × 10-5 2.13 0.186 0.462
18 BIEC2-416683 62115222 A 0.257 0.142 20.81 5.08 × 10-6 2.26 0.181 0.074
18 BIEC2-438214 62115702 T 0.259 0.153 17.49 2.88 × 10-5 2.17 0.187 0.382
18 BIEC2-438222 62118622 T 0.249 0.151 16.02 6.25 × 10-5 2.11 0.188 0.634
18 BIEC2-438227 62120598 C 0.255 0.153 17.53 2.83 × 10-5 2.17 0.188 0.372
18 BIEC2-416704 62148769 G 0.255 0.139 21.81 3.00 × 10 -6 2.32 0.182 0.042
18 BIEC2-416766 62757935 A 0.466 0.322 15.66 7.60 × 10-5 1.77 0.144 0.710
18 BIEC2-417495 67186093 G 0.314 0.184 16.24 5.59 × 10-5 1.91 0.163 0.589
21 BIEC2-574084 57039393 G 0.865 0.778 16.19 5.72 × 10-5 2.10 0.187 0.599
22 BIEC2-595969 38591767 C 0.790 0.674 15.51 8.21 × 10-5 1.90 0.162 0.724
22 BIEC2-596079 38680459 G 0.799 0.673 18.78 1.47 × 10-5 2.04 0.165 0.213
22 BIEC2-596530 39157841 C 0.706 0.575 17.53 2.82 × 10-5 1.84 0.147 0.371
22 BIEC2-596542 39169750 C 0.710 0.575 18.10 2.10 × 10-5 1.86 0.147 0.293
22 BIEC2-596546 39170079 A 0.671 0.547 15.48 8.35 × 10-5 1.76 0.143 0.728
  1. Genome-wide significant SNPs are shown in bold text. Corrected p-values were derived using 1000 permutations.