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Table 2 The thirty most significantly associated probes to smoking status after genome-wide correction

From: The effect of smoking on DNA methylation of peripheral blood mononuclear cells from African American women

    

Average beta values

  

Probe ID

Gene

Placement

Island status

Smokers

Non-smokers

T-test

Corrected p-value

cg19859270

GPR15

1stExon

 

0.77

0.87

2.44E-25

1.19E-19

cg05575921

AHRR

Body

N_Shore

0.68

0.83

2.54E-24

6.17E-19

cg08672695

 

N_Shelf

0.65

0.48

4.58E-20

7.40E-15

cg23576855

AHRR

Body

N_Shore

0.52

0.71

2.78E-17

3.37E-12

cg02657160

CPOX

Body

N_Shore

0.77

0.83

4.09E-17

3.97E-12

cg21161138

AHRR

Body

 

0.62

0.70

5.74E-17

4.64E-12

cg18230367

RNASE4

TSS200

N_Shore

0.05

0.07

2.13E-16

1.48E-11

cg02319016

PAK2

5'UTR

S_Shelf

0.70

0.56

1.53E-15

9.27E-11

cg26607002

NOSTRIN

TSS200

 

0.68

0.63

4.31E-15

2.32E-10

cg04677326

C19orf28

TSS200

Island

0.17

0.15

4.98E-15

2.42E-10

cg01940273

 

Island

0.50

0.59

5.69E-15

2.51E-10

cg05457881

C6orf218

TSS1500

 

0.18

0.22

6.91E-15

2.79E-10

cg06126421

  

0.65

0.76

7.79E-15

2.91E-10

cg21566642

 

Island

0.38

0.48

8.62E-15

2.99E-10

cg13086586

PAICS

Body

S_Shore

0.17

0.23

3.26E-14

1.05E-09

cg15281724

TXLNB

Body

 

0.78

0.69

9.63E-14

2.92E-09

cg15645254

NAALAD2

Body

 

0.78

0.75

1.23E-13

3.51E-09

cg19111030

ANKRD53

TSS1500

N_Shore

0.17

0.20

1.96E-13

5.30E-09

cg09741592

HNRNPA1

Body

S_Shore

0.18

0.23

3.23E-13

8.25E-09

cg08528204

TMEM116

TSS1500

S_Shore

0.17

0.20

8.77E-13

2.07E-08

cg17391741

 

N_Shore

0.82

0.85

8.97E-13

2.07E-08

cg15614155

 

N_Shore

0.83

0.78

1.06E-12

2.34E-08

cg05916255

ABCC2

Body

N_Shore

0.85

0.82

1.17E-12

2.47E-08

cg25223391

UVRAG

Body

 

0.71

0.67

1.31E-12

2.52E-08

cg00736283

ASF1B

TSS200

Island

0.13

0.11

1.32E-12

2.52E-08

cg26703534

AHRR

Body

S_Shelf

0.62

0.68

1.35E-12

2.52E-08

cg16851858

 

N_Shelf

0.73

0.77

1.55E-12

2.80E-08

cg02521854

 

N_Shelf

0.13

0.11

1.69E-12

2.93E-08

cg15658543

CARD11

5'UTR

 

0.88

0.85

1.91E-12

3.20E-08

cg13789443

GALNT11

5'UTR

S_Shore

0.60

0.55

2.00E-12

3.24E-08

  1. All average methylation values are non-log transformed beta-values. Island status refers to the position of the probe relative to the island. Classes include: 1) Island, 2) N (north) shore, 3) S (south) shore, 4) N (north) shelf, 5) S (south) shelf and 6) blank denoting that the probe does not map to an island.
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BMC Genomics

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