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Table 1 Nucleotide and complementary protein analyses for ω toxins

From: Diversification of a single ancestral gene into a successful toxin superfamily in highly venomous Australian funnel-web spiders

Sitea CodeML Tree SAAP Accessible surface areaf
Codon Amino Acid M2ab M8c Propertyd Magnitudee
21 E 0.99 ± 0.38 0.87 ± 0.42 - - -
(0.201) (0.257)
40 V 1.41 ± 0.49 1.47 ± 0.37 M W , M V , V0, μ 8, 8, 8, 8 42.0
(0.589) (0.842) Partially exposed
44 S 1.25 ± 0.37 1.28 ± 0.41 MW, M V , V0, μ 8, 8, 8, 8 82.1
(0.420) (0.647) Exposed
53 H 1.62 ± 0.63 1.55 ± 0.36 - - 0.0
(0.749) (0.929) Buried
57 G 1.39 ± 0.48 1.45 ± 0.38 - - 57.3
(0.570) (0.825) Exposed
60 T 0.80 ± 0.44 0.71 ± 0.41 - - 49.7
(0.122) (0.154) Exposed
64 N 0.53 ± 0.40 0.51 ± 0.30 - - 100.0
(0.031) (0.036) Exposed
69 T 1.34 ± 0.45 1.38 ± 0.40 - - 59.8
(0.507) (0.751) Exposed
72 R 1.10 ± 0.33 1.01 ± 0.42 - - 0.0
(0.26) (0.374) Buried
  1. aSites detected as positively selected using the integrative approach.
  2. bM2a Bayes empirical Bayes (BEB) posterior probability and post-mean ω indicated in parentheses.
  3. cM8 Bayes empirical Bayes (BEB) posterior probability and post-mean ω indicated in parentheses.
  4. dAmino acid property under selection (M W : molecular weight; M V : molecular volume; V0: partial specific volume; μ: Refractive index).
  5. eMagnitude if selection on the amino acid property.
  6. fAccessible surface area of 10–20% corresponds to buried residues, 40–50% indicates partially exposed amino acid residues, and ≥50% indicates solvent exposed residues.