Figure 1

The CT26 Genome. A) Circos diagram showing (outer to inner): cytogenetic bands in black, gray and white. Track 1: DNA copy number. Black: deleted; green: haploid; yellow: diploid; dark purple: triploid; light purple: tetraploid; dark blue: pentaploid; bright blue: hexaploid; red: higher copy number. Track 2: High confidence point mutations, plotted based on DNA allele frequency. Inner is allele frequency 0, outer is allele frequency 100. Colors are blue (0–40), green (40–60), orange (60–90), and red (90–100). Track 3: predicted MHC binding IC50 scores for missense mutations. Mutations in peptides likely to bind MHC are colored orange (IC50 < 500 nM). Track 4: insertions and deletions plotted according to allele frequency. B) DNA gene copy number. C) Single nucleotide mutation changes and the nucleotide immediately 3′ of the mutation. D) Mutation classification.