Figure 3

Layered Protein-Protein Interaction network (PPI) of 108 proteins. A layered network based on the subcellular localization of 640 proteins in the PPI was created. The nodes representing functionally important genes were highlighted in the layered network using colour codes - green (genes forming hub nodes in clusters (7), occurring in top 15 of ranked genes (108) and also present in putative biomarker dataset (38)); cyan (genes forming hub nodes in clusters, occurring in 108 AD genes and also present in putative biomarker dataset); yellow (genes occurring both in cluster hub and in 108 ranked genes); pink (genes forming hub nodes in clusters and occurring in top 15 of ranked genes); blue (remaining 59 from 108 list); red (38 biomarkers from AD, CSF and plasma overlap); grey (remaining proteins from 640 candidates).