Figure 3

QTL analyses of cell proliferation in the RMS of BXD RI strains. The x-axis for figures (A-C) represents the chromosomes 1–19, & X (top panel) and their physical maps in megabases (bottom panel). The y-axis and the blue line depict the likelihood ratio statistic (LRS), which indicates the strength of association between genotypes of markers across the genome and the phenotype (i.e. RMS linear density). The light red and gray horizontal lines mark the significant (P = 0.05) and suggestive (P = 0.63) threshold, respectively. Whole-genome interval mapping of unadjusted RMS linear density (A) and for the adjusted RMS linear density corrected for the effects of age (B) have mapped a significant QTL on Chr 6 (76.8-88.8 Mb) and a suggestive QTL on Chr 11 (50-58 Mb) regulating RMS linear density. (C) Composite interval mapping revealed an additional significant locus on Chr 14 (39–49.5 Mb) and a suggestive locus on Chr 18 (58–86 Mb) that work additively with the Chr 6 QTL in modulating RMS linear density.