Table 1 Strong candidate genes identified in the chromosomes (Chr) 6, 11, 14, and 18 QTL intervals
Gene symbol | Gene name | Chr | Gene location: start (Mb) | Gene length (kb) | SNPs | Indels | Gene Ontology (GO) annotation | Implicated in SVZ-RMS neurogenesis [ref.] | Implicated in SGZ neurogenesis [ref.] |
|---|---|---|---|---|---|---|---|---|---|
Tgfa | Transforming growth factor alpha | 6 | 86.145 | 79.742 | 6 | 3 | Positive regulation of cell division, negative regulation of apoptosis | ✔ [19] |  |
Anxa4 | Annexin A4 | 6 | 86.687 | 56.745 | 134 | 7 | Cell growth and survival, cell proliferation, carcinogenesis | Â | Â |
Gfpt1 | Glutamine fructose-6-phosphate transaminase 1 | 6 | 86.993 | 49.362 | 48 | 1 | Amino sugar and nucleotide sugar metabolism, cell regeneration | Â | Â |
Mcm2 | Minichromosome maintenance deficient 2 mitotin | 6 | 88.833 | 15.307 | 3 | 0 | DNA replication initiation, DNA unwinding during replication | ✔ [20] | ✔ [29] |
Ppp2ca | Protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform | 11 | 51.912 | 23.926 | 1 | 0 | Phosphoprotein phosphatase activity, meiosis, negative control of cell growth and division | Â | Â |
Rad50 | RAD50 homolog (S. cerevisiae) | 11 | 53.463 | 57.801 | 4 | 0 | DNA repair, homologous recombination, cell cycle | Â | Â |
Sparc | Secreted acidic cysteine rich glycoprotein | 11 | 55.208 | 25.580 | 83 | 5 | Response to growth factor stimulus, regulation of cell proliferation |  | ✔ [21] |
Cdkn3 | Cyclin-dependent kinase inhibitor 3 | 14 | 45.692 | 0.05 | 3 | 3 | Cell cycle arrest, phosphatase activity | Â | Â |
Gnpnat1 | Glucosamine-phosphate N-acetyltransferase 1 | 14 | 45.996 | 12.376 | 1 | 0 | Amino sugar and nucleotide sugar metabolism, actin dynamics, cell cycle progression | Â | Â |
Camk2a | Calcium/calmodulin-dependent protein kinase II alpha | 18 | 61.085 | 62.521 | 0 | 1 | G1/S transition of mitotic cell cycle, neuronal synaptic plasticity | Â | Â |
Seh1l | SEH1-like (S. cerevisiae) | 18 | 67.935 | 17.718 | 4 | 2 | Cell division, chromosome segregation, mitosis | Â | Â |
Smad4 | Similar to MAD homolog 4 (Drosophila) | 18 | 73.799 | 64.729 | 160 | 74 | Cell proliferation, tissue morphogenesis | ✔ [24] |  |
Elac1 | elaC homolog 1 (E. coli) | 18 | 73.895 | 19.442 | 42 | 7 | tRNA 3'-end processing, cell growth and proliferation | Â | Â |
Mapk4 | mitogen-activated protein kinase 4 | 18 | 74.088 | 136.463 | 141 | 70 | Cell cycle, protein amino acid phosphorylation | Â | Â |