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Table 1 Strong candidate genes identified in the chromosomes (Chr) 6, 11, 14, and 18 QTL intervals

From: Identification of genetic loci that modulate cell proliferation in the adult rostral migratory stream using the expanded panel of BXD mice

Gene symbol Gene name Chr Gene location: start (Mb) Gene length (kb) SNPs Indels Gene Ontology (GO) annotation Implicated in SVZ-RMS neurogenesis [ref.] Implicated in SGZ neurogenesis [ref.]
Tgfa Transforming growth factor alpha 6 86.145 79.742 6 3 Positive regulation of cell division, negative regulation of apoptosis ✔ [19]  
Anxa4 Annexin A4 6 86.687 56.745 134 7 Cell growth and survival, cell proliferation, carcinogenesis   
Gfpt1 Glutamine fructose-6-phosphate transaminase 1 6 86.993 49.362 48 1 Amino sugar and nucleotide sugar metabolism, cell regeneration   
Mcm2 Minichromosome maintenance deficient 2 mitotin 6 88.833 15.307 3 0 DNA replication initiation, DNA unwinding during replication ✔ [20] ✔ [29]
Ppp2ca Protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform 11 51.912 23.926 1 0 Phosphoprotein phosphatase activity, meiosis, negative control of cell growth and division   
Rad50 RAD50 homolog (S. cerevisiae) 11 53.463 57.801 4 0 DNA repair, homologous recombination, cell cycle   
Sparc Secreted acidic cysteine rich glycoprotein 11 55.208 25.580 83 5 Response to growth factor stimulus, regulation of cell proliferation   ✔ [21]
Cdkn3 Cyclin-dependent kinase inhibitor 3 14 45.692 0.05 3 3 Cell cycle arrest, phosphatase activity   
Gnpnat1 Glucosamine-phosphate N-acetyltransferase 1 14 45.996 12.376 1 0 Amino sugar and nucleotide sugar metabolism, actin dynamics, cell cycle progression   
Camk2a Calcium/calmodulin-dependent protein kinase II alpha 18 61.085 62.521 0 1 G1/S transition of mitotic cell cycle, neuronal synaptic plasticity   
Seh1l SEH1-like (S. cerevisiae) 18 67.935 17.718 4 2 Cell division, chromosome segregation, mitosis   
Smad4 Similar to MAD homolog 4 (Drosophila) 18 73.799 64.729 160 74 Cell proliferation, tissue morphogenesis ✔ [24]  
Elac1 elaC homolog 1 (E. coli) 18 73.895 19.442 42 7 tRNA 3'-end processing, cell growth and proliferation   
Mapk4 mitogen-activated protein kinase 4 18 74.088 136.463 141 70 Cell cycle, protein amino acid phosphorylation   
  1. Abbreviations: SNPs single-nucleotide polymorphisms, indels insertion/deletions.