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Table 4 Detailed information on the reported QTLs containing the 31 differentially expressed genes between the mammary gland of two cows with high milk protein and fat percentage and two cows with low protein and fat percentage

From: Transcriptional profiling of mammary gland in Holstein cows with extremely different milk protein and fat percentage using RNA sequencing

Gene name Position (bp) Position (cM)1 Previously reported QTL
  Distance to QTL peak (cM) CI and peak location (cM) Trait References
SAA3 26668046–26671801 Chr29: 36.8 12.6 Peak: 24.2 PP Bagnato et al., J Dairy Sci, 2008 [33]
HEATR7B2 33456348–33528569 Chr20: 37.5 5.6 20.2–43.5 (peak: 31.9) FP, PP Arranz et al., Anim Genet, 1998 [34]
6.3 37.8–49.7 (peak: 43.8) PP Ashwell et al., J Dairy Sci, 2004 [35]
0.2 Peak: 37.7 FP, PP Zhang et al., Genetics, 1998 [36]
5.2 15.5–68.0 (peak: 42.7) PP Bennewitz et al., Genetics, 2004 [37]
TRIB3 61176217–61187210 Chr13: 75.8 5.2 Peak: 81.0 PP Bagnato et al., J Dairy Sci, 2008 [33]
5.0 Peak: 80.8 FP, PP Pimentel et al., Anim Genet, 2011 [38]
SESN2 125698159–125714128 Chr2: 116.2 14.6 Peak: 101.6 FP, PP Pimentel et al., Anim Genet, 2011 [38]
HSPD1 86438978–86449372 Chr2: 81.0 6.5 Peak: 74.5 PP Bagnato et al., J Dairy Sci, 2008 [33]
NR4A1 27977006–27992869 Chr5: 32.5 12.1 29.4–45.5 (peak: 44.6) PP Bennewitz et al., Genet Sel Evol, 2003 [39]
SAA1 26693328–26696498 Chr29: 35.8 11.6 Peak: 24.2 PP Bagnato et al., J Dairy Sci, 2008 [33]
RPL23A 21526905–21574655 Chr11:27.8 5.8 Peak: 33.6 FP Ashwell et al., J Dairy Sci, 1998 [40]
8.4 Peak: 19.4 PP Bagnato et al., J Dairy Sci, 2008 [33]
VEGFA 17255946–17269998 Chr23: 25.8 2.5 20.7–41.9 (peak: 28.3) PP Viitala et al., J Dairy Sci, 2003 [41]
2.5 14.8–42.9 (peak: 28.3) PP Elo et al., Mamm Genome, 1999 [42]
KRT24 41557544–41561796 Chr19: 66.1 4.1 Peak: 70.2. PP Bagnato et al., J Dairy Sci, 2008 [33]
2.2 Peak: 63.9 PP Mosig et al., Genetics, 2001 [43]
4.0 Peak: 62.1 PP Bennewitz et al., Genetics, 2004 [37]
0.8 64.5–69.8 (peak: 66.9) FP Bennewitz et al., Genet Sel Evol, 2003 [39]
CDKN1A 10560498–10568780 Chr23: 16.1 12.4 14.8–42.9 (peak: 28.5) PP Elo et al., Mamm Genome, 1999 [42]
BoLA-DQB 25375269–25388620 Chr23: 38.2 9.9 14.8–42.9 (peak: 28.3) PP Elo et al., Mamm Genome, 1999 [42]
9.9 20.7–41.9 (peak: 28.3) PP Viitala et al., J Dairy Sci, 2003 [41]
4.7 Peak: 42.9 PP Bagnato et al., J Dairy Sci, 2008 [33]
PTHLH 82246521–82258858 Chr5: 90.7   76.2–103.1 PP Schrooten et al., J Dairy Sci, 2004 [44]
1.1 5.3–104.9 (peak: 89.6) FP Bennewitz et al., Genetics, 2004 [37]
11.6 34.1–108.3 (peak: 102.3) PP Bennewitz et al., Genetics, 2004 [37]
5.2 80.1–90.8 (peak: 85.5) FP Ashwell et al., J Dairy Sci, 2004 [35]
H4 31665561–31667068 Chr23: 46.8 3.9 Peak: 42.9 PP Bagnato et al., J Dairy Sci, 2008 [33]
DDIT3 56285007–56307931 Chr5: 61.2 28.4 6.9–102.6 (peak: 89.6) FP Bennewitz et al., Genetics, 2004 [37]
  32.3–69.7 PP Schrooten et al., J Dairy Sci, 2004 [44]
M-SAA3.2 26755567–26759547 Chr29: 37.8 13.6 Peak: 24.2 PP Bagnato et al., J Dairy Sci, 2008 [33]
HIST1H2AC 31579046–31589230 Chr23: 46.7 3.8 Peak: 42.9 PP Bagnato et al., J Dairy Sci, 2008 [33]
  1. 1The linkage position was estimated relative to UMD3.1.66 and based on the QTL mapper v.2.019 at http://www.animalgenome.org/cgi-bin/QTLdb/.
  2. PP: protein percentage; FP: fat percentage.