The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis

Table 1 Comparison of genes that exhibited Semax-induced alteration of expression levels after pMCAO

Gene symbol	Ischemia + semax 3 h		Ischemia + semax 24 h		ENTREZ GENE_ID
Gene symbol	lg (Ratio)	P-value	lg (Ratio)	P-value	ENTREZ GENE_ID
RGD1562905	0.58	1.1E-04	−0.53	2.1E-34	292539
Adamts1	0.34	5.2E-11	−0.25	7.5E-09	79252
Zfp36	0.24	5.5E-03	−0.16	2.0E-04	79426
Ptprcap	−0.28	2.3E-03	0.29	9.8E-08	499300
Ccdc53	−0.29	1.3E-06	0.18	4.6E-03	299707
RT1-Ba	−0.29	3.1E-07	0.36	1.5E-15	309621
Cd74	−0.30	1.6E-09	0.21	5.3E-06	25599
RT1-A1	−0.30	7.6E-10	0.29	2.8E-11	24973
H2-Ea	−0.31	4.1E-10	0.15	7.3E-04	294269
Igh-1a	−0.79	2.6E-30	0.47	3.5E-26	299352

The table shows the genes that exhibited significantly changed expression under Semax treatment at both time points (3 and 24 h). The logarithmic transformed value visually represents the symmetric changes in expression levels: negative value indicates decrease and positive value – increase of the gene expression level. The cut-off of gene-expression changes was 1.40. Ratio – relative expression level.

ISSN: 1471-2164