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Table 5 Association of TF motifs with Nfib and Nr3c1 common targets

From: An overlapping set of genes is regulated by both NFIB and the glucocorticoid receptor during lung maturation

Rank Motif Gene FC N f i b FCN r3c1 p a c t p r e p MAS
1 AR_full Ar - - 0.0013 0.97 2.86
2 TBR1_full Tbr1 NA - 0.0016 0.19 2.79
3 EBF1_full Ebf1 - - 0.0018 0.89 2.75
4 TBX2_full_2 Tbx2 - - 0.0020 0.37 2.71
5 ZNF410_DBD Zfp410 1.24 - 0.0025 0.90 2.60
6 NR3C2_DBD Nr3c2 - - 0.0036 0.82 2.44
7 Ar_DBD Ar - - 0.0038 0.93 2.42
8 NR3C1_DBD Nr3c1 - *3.14 0.0042 0.84 2.38
9 TBX1_DBD Tbx1 - - 0.0048 0.01 2.32
10 AR_DBD Ar - - 0.0054 0.75 2.26
11 EOMES_DBD Eomes NA - 0.0057 0.14 2.24
12 NFIB_full Nfib *2.75 2.17 0.0060 0.13 2.22
... ... ... ... ... ... ... ...
732 ESRRB_DBD Esrrb NA 1.31 0.10 0.0071 -2.15
733 MEF2A_DBD Mef2a 0.72 - 0.91 0.0060 -2.22
734 POU3F1_DBD_2 Pouf3f1 NA NA 0.97 0.0050 -2.30
735 ESRRG_full_3 Esrrg - - 0.14 0.0038 -2.42
736 OTX1_DBD Otx1 NA NA 0.78 0.0036 -2.44
737 Esrra_DBD_2 Esrra NA NA 0.03 0.0008 -3.10
738 ESRRA_DBD Esrra NA NA 0.13 0.0005 -3.26
739 FOXI1_full_2 Foxi1 NA - 0.62 <10-4 -4.01
  1. The table shows the rank of the MAS score (rank), the motif name (motif), the associated gene name (gene), the expression fold-change (FC) of the gene in each KO, the (unadjusted) motif enrichment p-value in the activated set of genes (p a c t ), the (unadjusted) motif enrichment p-value in the repressed set of genes (p r e p ) and the motif association score (MAS). β€œNA” indicates that no expression data is available for the TF gene and β€œ-” indicates that expression change is not significant (p-value >0.05). Motif names all in uppercase are for human TFs, others are for mouse TFs. *Note that these FC apply to the disrupted transcripts, and that no functional protein is produced for Nfib and Nr3c1.