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Table 5 Networks generated from endometrial gene expression data of HF versus LF heifers by IPA

From: Global gene expression in endometrium of high and low fertility heifers during the mid-luteal phase of the estrous cycle

Network ID Top functions Molecules in network Score Focus molecules
1 Lipid Metabolism, Small Molecule Biochemistry ACTB, ADCY2, ADCY3, ANXA6, ARHGDIG, CACNB2, Calmodulin, CNOT8, CTSL2, ERK, F Actin, FAU, FKBP7, FKBP10, FLNC, FSH, GJA1, GUCY, hCG, IFI6, IL33, Lh, MARCKS (includes EG:4082), NPPC, NR0B1, NTN4, Peptidylprolyl isomerase, PHLDA1, Pkc(s), PPIH, Rock, RPLP1, RPLP2, SRD5A1, TP53I11 45 25
2 Cellular Growth and Proliferation, Connective Tissue Development and Function, Skeletal and Muscular System Development and Function ACTA2, Alpha Actinin, CAT, CIAO1, COL1A2, Collagen type I, Collagen(s), COPB2, CSRP1, CSRP2, CXCL2, ENPP1, FERMT2, FHL2, FHL3, FST, G-Actin, GADD45B, GEFT, HSPB1, Integrin, Laminin, LTBP1, MAGED1, MMP19, MYLK, NFkB (complex), Pak, Pdgf, PJA1, RARRES2, RIT1, SERPINH1, Tgf beta, TGFB1I1 45 25
3 Carbohydrate Metabolism, Haematological Disease, Metabolic Disease 26 s Proteasome, Akt, AMPK, EIF2C4, ELOVL5, FASN, GLUL, HISTONE, Histone h3, Histone h4, HMG20B, Hsp90, MAP3K7IP2, MED13, MED27, N-cor, ODC1, PPARA, PSMB10, PSMD2, PSMD11, PTPRK, RAB3B, RBBP7, RCAN2, RPL23, RPS3, RPS5, SFRP1, SMOC2, SOX6, SRPK2, T3-TR-RXR, Ubiquitin, UCP3 44 25
4 Cell Death, Gene Expression, Lipid Metabolism ACAT1, Caspase, CD58, CMPK1, ERK1/2, FUS, HMGB1 (includes EG:3146), IFN Beta, IgG, IL1, IL12 (complex), IL6ST, ILF3, IMPDH2, Insulin, Interferon alpha, Jnk, LDL, LGALS1, LGALS3, LRAT, Mapk, Mek, NES, P38 MAPK, PCCB, PDGF BB, PI3K, PIBF1, PRMT1, RABEP1, Ras, SLC25A12, STAT5a/b, TNIK 28 18
5 Cell Morphology, Inflammatory Response, Lipid Metabolism ARHGDIG, ARHGEF, ARHGEF11, CPS1, EMP3, ETFDH, FAU, FNBP1, GLI3, IFI6, LARP1, LEP, Lpa receptor, P2RX7, Pka, PLXNB2, PXN, RAGE, Ras homolog, RCN3, RGNEF, RHOH, RHOU, RHPN1, RND2, RPL8, RPL26, RPL29 (includes EG:6159), RPLP2, SCAMP2, St3gal, ST3GAL3, TNF, UCP3, YWHAZ 27 17
6 Drug Metabolism, Small Molecule Biochemistry, Cell-To-Cell Signalling and Interaction ABHD5, ALDH3A2, BAG3, BCL2, beta-estradiol, BIK, BOC, C1QTNF6, CDON, CTNNB1, CTSH, CXADR, EEF2, F12, FOLH1, GADD45B, GIMAP5, HOXC6, HSPB8, IFT122, IGFBP6, KCNMB1, METTL7A, MME, MRVI1, PLIN2, PLIN5, PNPLA2, PTGIS, PTPRK, PTPRU, SEMA5A, SFRP1, SULT1A1, SULT1A3 25 17
7 Embryonic Development, Organ Development, Organ Morphology Arginase, AZGP1, BMP6, C12ORF11, C19ORF10, C21ORF7, CALM2, COL16A1, COL4A6, CSRP2, CTSH, CTSL2, DBNDD2, DPYSL3, DYRK2, ENPP1, GOLGA7, HRAS, HTT, IFNG, IL13, LPHN2, LRBA, LY6E, Pdgf, PLOD1, RAB12, RAB33A, SLC1A3, SRM, SV2A, TCF12, TGFB1, UNC5B, ZDHHC9 23 15
8 Developmental Disorder, Neurological Disease, Cell Death ADAM10, AHCYL2, BCL2L14, CABC1, CORO2A, DUT (includes EG:1854), ERH, F11R, GRPR, LETMD1, MAPK1, MARCKS (includes EG:4082), MEST, NFATC2IP, NMB, NMBR, NMT1, NR3C1, PARK7, PLK3, PMM1, PRKRA, PRPSAP1, REEP5, RNF144B, SH3D19, SLC45A2, SMN1, SNUPN, SPOP, TP53, TRAF6, UBE2T, ZNF259, ZNF346 22 15
9 Cellular Development, Cell Cycle, Connective Tissue Development and Function ABCD3, ACTC1, Actin, ATP13A5, ATP5J2, ATPase, CDKN2A, CLPX, DDX19B, DONSON, FAM167A, GPHN, HIP1R, HLTF, KATNA1, MED27, MIR373, MIR297-2, NCALD, NSF, ORC5L, PACRGL, PHACTR1, phosphatidylinositol 3,4-diphosphate, PLS1, POLR2H, RNA polymerase II, RSPO1, SDCCAG3 (includes EG:10807), SNX16, SUOX, TBX3, TERT, TOB2, VIM 21 14
10 Post-Translational Modification, Cell Cycle, Gene Expression ACAA1B, CPT2, CUEDC2, DAP, EHHADH, ERBB2, ESR1, FRRS1, GALNT1, GALNT2, GALNT3, GALNT6, HCG 2023776, IGFBP6, LAMP1, LAMP2, MMS19, MRC1, MYC, NCOA4, OLFML3, PAICS, PHF5A, Polypeptide N-acetylgalactosaminyltransferase, PPARG, PTRF, QKI, RAB34, SCG5, SETDB1, SFRP1, STIM1, TPD52, WWC1 19 13
11 Cancer, Cardiovascular Disease, Cell-To-Cell Signalling and Interaction ALX1, APEH, C20ORF160, COPB2, COX2, COX4I1, DAG1, EPO, FOS, GMFB, GRB2, GRP, GSTK1, GYLTL1B, HCLS1, HNRNPH2, HNRNPR, Hydrolase, KHSRP, MST1R, ONECUT1, P2RY1, PDE6C, PDE6G, POP7, RAB3GAP1, RCC2, RNF128, RPL7, RPS7, RPS18, SMARCD2, TMEM62, USP8, YPEL5 19 13
12 Embryonic Development, Tissue Development, Tissue Morphology ACOT13, APBB1, BACE1, C11ORF52, CBS, CELA1, Coup-Tf, DCK, DKK1, DSC2, FOXA1, HMGB2, HNF4A, IER5L, JKAMP, KRR1, LRP, LRP2, LRP5, LRP6, MESDC2, NR2F1, NR2F2, PARP4, PHB (includes EG:5245), PKP2, Plasminogen Activator, POU5F1, RSPRY1, Secretase gamma, SLC17A5, TXNDC12, UBE2D3 (includes EG:7323), UBE2V1, WNT4 19 13