Table 5 Networks generated from endometrial gene expression data of HF versus LF heifers by IPA

1

Lipid Metabolism, Small Molecule Biochemistry

ACTB, ADCY2, ADCY3, ANXA6, ARHGDIG, CACNB2, Calmodulin, CNOT8, CTSL2, ERK, F Actin, FAU, FKBP7, FKBP10, FLNC, FSH, GJA1, GUCY, hCG, IFI6, IL33, Lh, MARCKS (includes EG:4082), NPPC, NR0B1, NTN4, Peptidylprolyl isomerase, PHLDA1, Pkc(s), PPIH, Rock, RPLP1, RPLP2, SRD5A1, TP53I11

2

Cellular Growth and Proliferation, Connective Tissue Development and Function, Skeletal and Muscular System Development and Function

ACTA2, Alpha Actinin, CAT, CIAO1, COL1A2, Collagen type I, Collagen(s), COPB2, CSRP1, CSRP2, CXCL2, ENPP1, FERMT2, FHL2, FHL3, FST, G-Actin, GADD45B, GEFT, HSPB1, Integrin, Laminin, LTBP1, MAGED1, MMP19, MYLK, NFkB (complex), Pak, Pdgf, PJA1, RARRES2, RIT1, SERPINH1, Tgf beta, TGFB1I1

3

Carbohydrate Metabolism, Haematological Disease, Metabolic Disease

26 s Proteasome, Akt, AMPK, EIF2C4, ELOVL5, FASN, GLUL, HISTONE, Histone h3, Histone h4, HMG20B, Hsp90, MAP3K7IP2, MED13, MED27, N-cor, ODC1, PPARA, PSMB10, PSMD2, PSMD11, PTPRK, RAB3B, RBBP7, RCAN2, RPL23, RPS3, RPS5, SFRP1, SMOC2, SOX6, SRPK2, T3-TR-RXR, Ubiquitin, UCP3

4

Cell Death, Gene Expression, Lipid Metabolism

ACAT1, Caspase, CD58, CMPK1, ERK1/2, FUS, HMGB1 (includes EG:3146), IFN Beta, IgG, IL1, IL12 (complex), IL6ST, ILF3, IMPDH2, Insulin, Interferon alpha, Jnk, LDL, LGALS1, LGALS3, LRAT, Mapk, Mek, NES, P38 MAPK, PCCB, PDGF BB, PI3K, PIBF1, PRMT1, RABEP1, Ras, SLC25A12, STAT5a/b, TNIK

5

Cell Morphology, Inflammatory Response, Lipid Metabolism

ARHGDIG, ARHGEF, ARHGEF11, CPS1, EMP3, ETFDH, FAU, FNBP1, GLI3, IFI6, LARP1, LEP, Lpa receptor, P2RX7, Pka, PLXNB2, PXN, RAGE, Ras homolog, RCN3, RGNEF, RHOH, RHOU, RHPN1, RND2, RPL8, RPL26, RPL29 (includes EG:6159), RPLP2, SCAMP2, St3gal, ST3GAL3, TNF, UCP3, YWHAZ

6

Drug Metabolism, Small Molecule Biochemistry, Cell-To-Cell Signalling and Interaction

ABHD5, ALDH3A2, BAG3, BCL2, beta-estradiol, BIK, BOC, C1QTNF6, CDON, CTNNB1, CTSH, CXADR, EEF2, F12, FOLH1, GADD45B, GIMAP5, HOXC6, HSPB8, IFT122, IGFBP6, KCNMB1, METTL7A, MME, MRVI1, PLIN2, PLIN5, PNPLA2, PTGIS, PTPRK, PTPRU, SEMA5A, SFRP1, SULT1A1, SULT1A3

7

Embryonic Development, Organ Development, Organ Morphology

Arginase, AZGP1, BMP6, C12ORF11, C19ORF10, C21ORF7, CALM2, COL16A1, COL4A6, CSRP2, CTSH, CTSL2, DBNDD2, DPYSL3, DYRK2, ENPP1, GOLGA7, HRAS, HTT, IFNG, IL13, LPHN2, LRBA, LY6E, Pdgf, PLOD1, RAB12, RAB33A, SLC1A3, SRM, SV2A, TCF12, TGFB1, UNC5B, ZDHHC9

8

Developmental Disorder, Neurological Disease, Cell Death

ADAM10, AHCYL2, BCL2L14, CABC1, CORO2A, DUT (includes EG:1854), ERH, F11R, GRPR, LETMD1, MAPK1, MARCKS (includes EG:4082), MEST, NFATC2IP, NMB, NMBR, NMT1, NR3C1, PARK7, PLK3, PMM1, PRKRA, PRPSAP1, REEP5, RNF144B, SH3D19, SLC45A2, SMN1, SNUPN, SPOP, TP53, TRAF6, UBE2T, ZNF259, ZNF346

9

Cellular Development, Cell Cycle, Connective Tissue Development and Function

ABCD3, ACTC1, Actin, ATP13A5, ATP5J2, ATPase, CDKN2A, CLPX, DDX19B, DONSON, FAM167A, GPHN, HIP1R, HLTF, KATNA1, MED27, MIR373, MIR297-2, NCALD, NSF, ORC5L, PACRGL, PHACTR1, phosphatidylinositol 3,4-diphosphate, PLS1, POLR2H, RNA polymerase II, RSPO1, SDCCAG3 (includes EG:10807), SNX16, SUOX, TBX3, TERT, TOB2, VIM

10

Post-Translational Modification, Cell Cycle, Gene Expression

ACAA1B, CPT2, CUEDC2, DAP, EHHADH, ERBB2, ESR1, FRRS1, GALNT1, GALNT2, GALNT3, GALNT6, HCG 2023776, IGFBP6, LAMP1, LAMP2, MMS19, MRC1, MYC, NCOA4, OLFML3, PAICS, PHF5A, Polypeptide N-acetylgalactosaminyltransferase, PPARG, PTRF, QKI, RAB34, SCG5, SETDB1, SFRP1, STIM1, TPD52, WWC1

11

Cancer, Cardiovascular Disease, Cell-To-Cell Signalling and Interaction

ALX1, APEH, C20ORF160, COPB2, COX2, COX4I1, DAG1, EPO, FOS, GMFB, GRB2, GRP, GSTK1, GYLTL1B, HCLS1, HNRNPH2, HNRNPR, Hydrolase, KHSRP, MST1R, ONECUT1, P2RY1, PDE6C, PDE6G, POP7, RAB3GAP1, RCC2, RNF128, RPL7, RPS7, RPS18, SMARCD2, TMEM62, USP8, YPEL5

12

Embryonic Development, Tissue Development, Tissue Morphology

ACOT13, APBB1, BACE1, C11ORF52, CBS, CELA1, Coup-Tf, DCK, DKK1, DSC2, FOXA1, HMGB2, HNF4A, IER5L, JKAMP, KRR1, LRP, LRP2, LRP5, LRP6, MESDC2, NR2F1, NR2F2, PARP4, PHB (includes EG:5245), PKP2, Plasminogen Activator, POU5F1, RSPRY1, Secretase gamma, SLC17A5, TXNDC12, UBE2D3 (includes EG:7323), UBE2V1, WNT4