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Table 2 Functional analysis of biomarkers that distinguish 14 class compounds

From: Identification of biomarkers that distinguish chemical contaminants based on gene expression profiles

Category p-value No of genes Molecules
Cell Cycle 3.88E-29-2.23E-02 42 KIF23, KIF20A, CDC20, PTTG1, CCNB2, DSN1, KNTC1, MKI67, NUF2, AURKB, TTK, SKA1, BIRC5, RAD51, CCNA2, NEK2, TOP2A, CDKN3, KIF2C, ECT2, KIFC1, NCAPH, TRIP13, TACC3, ESPL1, CCNB1, RACGAP1, SPC25, PRC1, KIF4A, CKAP2, PLK1, FOXM1, BUB1B, CDC2, NCAPG2, BUB1, CCNE1, MCM2, KIF20B, NDC80, UBE2C
Cellular assembly and organization 8.61E-23-2.16E-02 33 KIF23, PTTG1, CCNB2, DSN1, AURKB, TTK, NUF2, SKA1, BIRC5, RAD51, CCNA2, NEK2, EZR, TOP2A, KIF2C, ECT2, NCAPH, KIFC1, TACC3, ESPL1, CCNB1, KIF4A, PRC1, SPC25, PLK1, CKAP2, BUB1B, NCAPG2, CDC2, BUB1, CCNE1, KIF20B, NDC80
DNA replication, recombination, and repair 8.61E-23-2.16E-02 44 KIF23, MCM6, CDC20, KIAA0101, PTTG1, CCNB2, DSN1, KNTC1, AURKB, TTK, NUF2, PBK, SKA1, BIRC5, RAD51, CCNA2, NEK2, TOP2A, KIF2C, ECT2, NCAPH, KIFC1, EXO1, MCM5, TRIP13, TACC3, ESPL1, CCNB1, KIF4A, SPC25, PRC1, CKAP2, PLK1, FOXM1, BUB1B, NCAPG2, CDC2, MCM3, BUB1, CCNE1, MCM2, POLA2, NDC80, TK1
Cellular movement 3.82E-18-1.73E-02 13 KIF23, KIF20A, CCNB1, CDC20, RACGAP1, KIF4A, PRC1, PLK1, AURKB, KIF20B, TOP2A, ECT2, KIFC1
Cell death 5.84E-08-2.44E-02 28 CDC20, PTTG1, TTK, NUF2, LMNB1, BIRC5, RAD51, CCNA2, NEK2, EZR, TOP2A, TACC3, CCNB1, ESPL1, PCSK9, SPC25, RRM2, PLK1, CKAP2, BUB1B, FOXM1, CDC2, NCAPG2, BUB1, CCNE1, MCM2, TK1, UBE2C
Cellular compromise 1.87E-05-1.73E-02 13 KIF23, TACC3, CCNB1, PTTG1, PLK1, CDC2, BIRC5, NEK2, EZR, TOP2A, NDC80, KIF2C, ECT2
Cellular growth and proliferation 5.43E-05-2.39E-02 32 KIF20A, KIF23, KIAA0101, PTTG1, MKI67, TTK, PBK, BIRC5, RAD51, CCNA2, NEK2, EZR, CDKN3, KIF2C, E2F8, MCM5, TACC3, ESPL1, CCNB1, PRC1, RRM2, PLK1, FOXM1, BUB1B, CDC2, MCM3, BUB1, CCNE1, MCM2, KIF20B, TCF19, UBE2C