The HGCS interface. (A) The two boxes contain the list of genes to prioritize/analyze (which can be acquired from any high-throughput experiment after the application of filters; alternatively, any user-defined list of candidate genes can be used), and the core genes (known to be associated with the phenotype) for ranking purposes. A scroll box allows a choice of metrics for ranking (distance, p-value, or best reciprocal p-value), and the user may choose whether to rank the results globally, or separately by core gene. (B) The output consists of a table of genes ranked with respect to the core genes, which can be downloaded as a tab-separated text file. The information about the nature of connectivity between the core and target genes provided includes HGC-predicted biological distance, ranking of the target gene in the connectome of the core gene, the ratio between biological distance and the genome-wide median and mean biological distances to the core gene, the sphere of the target gene around the core gene, degrees of separation between the genes, and the full gene name.