Table 1 Pathways and altered genes involved in signal transduction, immune system, digestive system and endocrine system
KEGG category | KEGG subcategory | KEGG pathways | Transcripts |
|---|---|---|---|
Environmental Information Processing | Signal Transduction | Wnt signaling pathway | PPP2R5C, FBXW11, SMAD4, WNT5B, PRKCA |
MAPK signaling pathway | TGFB1, FGF12, CACNA1B, CRK, FGFR1, PRKCA, MAP4K3, MAP3K11 | ||
TGF-beta signaling pathway | TGFB1, SMAD5, LTBP1, SMAD4, BMP4 | ||
mTOR signaling pathway | ULK2, PRKAA1, HIF1A | ||
Calcium signaling pathway | PDE1A, CACNA1B, GNAL, HTR2A, ERBB4, ADCY9, PHKA1, PDE1B, PRKCA, NOS2A | ||
ErbB signaling pathway | CRK, ERBB4, CDKN1B, PRKCA | ||
Phosphatidylinositol signaling system | DGKI, PRKCA, INPP4B | ||
Jak-STAT signaling pathway | LEPR, LIF | ||
Hedgehog signaling pathway | FBXW11, WNT5B, BMP4 | ||
VEGF signaling pathway | PRKCA | ||
Organismal Systems | Immune System | Intestinal immune network for IgA production | TGFB1 |
Chemokine signaling pathway | CCL8, CRK, ADCY9, VAV2 | ||
Hematopoietic cell lineage | CD55 | ||
Complement and coagulation cascades | CD55, TFPI, C5AR1 | ||
Fc gamma R-mediated phagocytosis | CRK, PPAP2A, PRKCA, VAV2 | ||
Leukocyte transendothelial migration | CTNNA3, CLDN10, MMP9, PRKCA, VAV2 | ||
Natural killer cell mediated cytotoxicity | FCER1G, PRKCA, VAV2 | ||
Fc epsilon RI signaling pathway | FCER1G, BTK, PRKCA, VAV2 | ||
Toll-like receptor signaling pathway | MYD88, IRF7 | ||
B cell receptor signaling pathway | BTK, VAV2 | ||
RIG-I-like receptor signaling pathway | ATG5, IRF7 | ||
Cytosolic DNA-sensing pathway | IRF7 | ||
T cell receptor signaling pathway | VAV2 | ||
Digestive System | Vitamin digestion and absorption | SLC23A1 | |
Mineral absorption | CYBRD1, ATP1B2, ATP1A2, ATP7A | ||
Fat digestion and absorption | PPAP2A | ||
Salivary secretion | ATP1B2, ATP1A2, ADCY9, PRKCA | ||
Gastric acid secretion | ATP1B2, ATP1A2, SSTR2, ADCY9, PRKCA | ||
Pancreatic secretion | ATP1B2, ATP1A2, ADCY9, CLCA1, PRKCA | ||
Bile secretion | ATP1B2, ATP1A2, ABCB11, ADCY9, ABCB1 | ||
Carbohydrate digestion and absorption | ATP1B2, ATP1A2, SLC2A2 | ||
Protein digestion and absorption | ATP1B2, ATP1A2, COL11A1 | ||
Endocrine System | Progesterone-mediated oocyte maturation | CDC27, SPDYA, ADCY9, CCNA1 | |
Insulin signaling pathway | CRK, PCK2, PRKAA1, PHKA1, IRS4, FLOT2 | ||
Adipocytokine signaling pathway | ACSBG1, PCK2, LEPR, ADIPOQ, PRKAA1, IRS4 | ||
PPAR signaling pathway | ACSBG1, PCK2, ADIPOQ, FABP7, PLTP | ||
GnRH signaling pathway | ADCY9, PRKCA | ||
Melanogenesis | ADCY9, WNT5B, PRKCA |