Visual gene-network analysis reveals the cancer gene co-expression in human endometrial cancer

BMC Genomics

Table 2 List of hub gene associated with grade, type and stage o ECs

Symbol	Gene names	Hub gene significance^*
		f	K	GS
Hub genes for grade
TP53	Tumor protein 53	954	0.40	0.31
AURKB	Aurora kinase B	885	0.41	0.37
BUB1	Budding uninhibited by benzimidazoles 1	768	0.43	0.42
CENPA	Centromere protein A	764	0.44	0.42
Hub genes for type
AURKB	Aurora kinase B	995	0.41	0.35
PRC1	Protein regulator of cytokinesis 1	893	0.34	0.33
CDC6	Cell division cycle 6	849	0.26	0.24
E2F2	E2F transcription factor 2	776	0.31	0.22
KIF20A	Kinesin family member 20A	760	0.46	0.21
Hub genes for stage (derived from module yellow)
BUB1	Budding uninhibited by benzimidazoles 1	768	0.43	0.42
FEN1	Flap structure-specific endonuclease 1	764	0.27	0.32
KIF23	Kinesin family member 23	763	0.34	0.27
CDC20	Cell division cycle 20	762	0.37	0.32
PRC1	Protein regulator of cytokinesis 1	760	0.34	0.27
Hub genes for stage (derived from module blue)
IDH3G	Isocitrate dehydrogenase 3 (NAD+) gamma	934	0.36	0.49
NDUFV2	NADH dehydrogenase (ubiquinone) flavoprotein 2	873	0.35	0.42
ATP5B	ATP synthase, H + transporting, mitochondrial F1 complex, beta polypeptide	769	0.52	0.49
PSMB3	Proteasome (prosome, macropain) subunit, beta type, 3	762	0.41	0.47
PSMB7	Proteasome (prosome, macropain) subunit, beta type, 7	760	0.32	0.42

*This study defined the hub gene significance (HGS) by integrating WGCNA and elastic-net analysis, estimating the gene significance (GS), scaled connectivity (K) and frequency (f). Only genes present in GS > 0.2, K > 0.2 and f > 750 were selected as ECs-specific hub genes.

ISSN: 1471-2164