Gene | Allele | Allele mutation | Molecular identity | Support | Confirmation status | Human ortholog | Associated human conditions | References |
---|---|---|---|---|---|---|---|---|
lin-6/mcm-4 | h92 | C > * | Mini chromosome maintenance | RNAi | Confirmed1 | MCM4 | Natural killer cell and glucocorticoid deficiency with DNA repair defect | [39] |
let-354/dhc-1 | h79 | Q > * | Dynein heavy chain | Both | Confirmed1 | DYNC1H1 | Charcot-Marie-Tooth disease, Mental retardation, Spinal muscular atrophy | |
let-502/rock | h392 | Q > * | Rho associated kinase | RNAi | Confirmed1 | ROCK1 |  | [43] |
let-363/tor | h98 | Splice variant | Tor kinase | Both | Confirmed1 | MTOR | pancreatic neuroendocrine tumors | |
 | h420a | Q > * |  |  | Confirmed3 |  |  |  |
 | h502a | Splice variant |  |  | Confirmed3 |  |  |  |
let-603/air-2 | h289 | W > * | Aurora-related serine/threonine kinase | Both | Confirmed1 | AURKA | Susceptibility to colon cancer | [46] |
let-512/vps-34 | h797 | P > S | phosphoinositide 3-kinase |  | Confirmed1 | PIK3C3 |  | [47] |
let-381/foxf | h107 | splice variant | Forkhead transcription factor F | K.O. | Confirmed1 | FOXF2 | Â | [48] |
let-607/bZip | h402 | Q > * | Leucine zipper transcription factor | Both | Confirmed1 | CREB3L3 |  | [49] |
let-504/E01A2.4 | h448 | M > I | NFkB activating protein | Both | Confirmed1 | NKAP |  |  |
let-152/ccb-1 | h685 | W > * | Calcium channel subunit |  | Confirmed2 | CACNB2 | Brugada syndrome 4 |  |
let-355/hel/T05E8.3 | h81 | Y > * | DEAD/H helicase | RNAi | Confirmed2 | DHX33 |  |  |
let-362/rhel/Y71G12B.8 | h86 | R > * | DEAD/H RNA helicase | RNAi | Confirmed2 | DDX27 |  |  |
let-366/aars-2 | h112 | Q > * | Alanine tRNA synthetase | RNAi | Confirmed2 | AARS | Charcot-Marie-Tooth disease | [50] |
let-368/inx-12 | h121 | W > * | Innexin gap junction | K.O. | Confirmed2 |  |  |  |
let-370/coq-1 | h128 | G > E | hexaprenyl pyrophosphate synthetase | K.O. | Confirmed2 | PDSS1 | Coenzyme Q10 deficiency, Parkinson’s disease | [51] |
let-389/nars-1 | h680 | G > E | Asparagine tRNA synthetase | Both | Confirmed2 | NARS |  |  |
let-396/fars-1 | h217 | Q > * | Phenylalanine tRNA synthetase | RNAi | Confirmed2 | FARSA |  |  |
let-522/hlh-2 | h735 | W > * | Helix loop helix transcription factor | Both | Confirmed2 | TCF3 | Acute lymphoblastic leukemia |  |
let-529/asd-2 | h238 | Q > * | KH domain containing RNA binding protein | RNAi | Confirmed2 | QKI | Mental retardation |  |
let-575/ptr-2 | h345 | W > * | Sterol sensing domain protein | RNAi | Confirmed2 | PTCHD1 | Autism spectrum disorders | |
let-585/inx-13 | h784 | W > * | Innexin gap junction | RNAi | Confirmed2 |  |  |  |
let-595/imb-1 | h353 | R > * | Importin | RNAi | Confirmed2 | KPNB1 |  |  |
let-598/F27C1.6 | h213 | Q > * | U3 small nucleolar ribonucleoprotein | RNAi | Confirmed2 | UTP14C |  |  |
let-599/nath-10 | h290 | L > F | N-acetyl transferase | Both | Confirmed2 | NAT10 |  |  |
let-608/ncbp-1 | h706 | Q > * | Nuclear cap binding protein | RNAi | Confirmed2 | NCBP1 |  |  |
let-611/C48E7.2 | h756 | Q > * | RNA polymerase III subunit | RNAi | Confirmed2 | POLR3C |  |  |
let-612/apm-1 | h466 | splice variant | Adaptin subunit | RNAi | Confirmed2 | AP1M1 | Â | Â |
let-365/sep-1 | h108 | W > * | Separase | Both | Confirmed2 | ESPL1 | Breast cancer oncogene |  |
let-364/mat-1 | h104 | S > F | Anaphase promoting complex subunit | RNAi | Confirmed2 | CDC27 |  |  |
let-101/npp-6 | h242 | W > * | Nuclear pore complex protein | Both | Confirmed2 | NUP160 |  |  |
let-106/hcp-6 | h787 | C > Y | Condensin subunit | Both | Confirmed2 | NCAPD3 |  |  |
let-379/tag-345 | h127 | W > * | Nucleolar protein complex member | RNAi | Confirmed2 | WDR12 |  |  |
let-503/R12E2.2 | h313 | Q > * | Protein of unknown function | K.O. | Confirmed2 | SUCO |  |  |
let-517/spg-7 | h264 | G > E | Metalloprotease | Both | Confirmed2 | AFG3L2 | Spastic ataxia, Spinocerebellar ataxia |  |
let-597/hcp-4 | h349 | E > * | Holocentromeric protein | RNAi | Confirmed2 | CENPC |  |  |
let-630/Y110A7A.19 | h355b | R > * | Pentatricopeptide repeat containing protein | RNAi | Confirmed2 | PTCD3 |  |  |
 | h782b | W > * |  |  | Confirmed2 |  |  |  |
let-646/pat-10 | h233 | G > E | Troponin C | RNAi | Confirmed2 | TNNC1 | Cardiomyopathy |  |
let-526 | h799c | Q > * | SWI/SNF complex subunit | Both | Confirmed3 | ARID1A | Mental retardation |  |
 | h405c | W > * |  |  | Confirmed3 |  |  |  |
let-129/zfh-2 | h379 | Q > * | zinc finger homeobox protein | Both | Prediction | ZFHX3, ZFHX4 | Susceptibility to prostate cancer, Ptosis |  |
let-147/rnp-6 | h463 | G > E | RNA splicing factor | RNAi range | Prediction | PUF60 | Verheij syndrome |  |
let-373/unc-73 | h234 | Del | Guanine nucleotide exchange factor | Both | Prediction | TRIO | Â | Â |
let-377/lim-7 | h110 | W > * | LIM homeodomain protein | K.O. | Prediction | ISL2 |  |  |
let-378/dnj-21 | h124 | G > E | DnaJ domain containing protein | RNAi | Prediction | DNAJC15 |  |  |
let-380/knl-2 | h80 | W > * | Centromeric protein | Both | Prediction |  |  |  |
let-382/nuo-2 | h82 | Q > * | Mitochondria complex I subunit | Both | Prediction | NDUFS3 | Leigh syndrome, Mitochondrial complex I deficiency |  |
let-383/T21G5.6 | h115 | W > * | Protein of unknown function |  | Prediction |  |  |  |
let-384/C06A5.1 | h84 | Q > * | Integrator subunit | RNAi | Prediction | INTS1 |  |  |
let-385/teg-4 | h85 | splice variant | splicing factor | RNAi | Prediction | SF3B3 | Â | Â |
let-386/dbr-1 | h117 | G > E | RNA lariat-debranching enzyme | RNAi range | Prediction | DBR1 |  |  |
let-391/tag-146 | h91 | Q > * | Uncharacterized zinc finger protein | K.O. | Prediction |  |  |  |
let-397/rpb-5 | h228 | Q > * | RNA polymerase II subunit | RNAi | Prediction | POLR2E |  |  |
let-400/prpf-4 | h269 | D > G | Pre-mRNA processing factor | RNAi | Prediction | PRPF4B |  | [55] |
let-509/unc-73 | h142 | W > * | Guanine nucleotide exchange factor | Both | Prediction | TRIO |  |  |
let-527/nhr-23 | h207 | R > Q | Nuclear hormone receptor | Both | Prediction | RORC |  |  |
let-534/ahcy-1 | h260 | Q > * | S-adenosylhomocysteine hydrolase | Both | Prediction | AHCY | Hypermethioninemia |  |
let-581/unc-11 | h725 | A > V | clathrin adaptor protein | RNAi; Range | Prediction | PICALM | Acute lymphoblastic leukemia, Acute T-cell lymphoblastic leukemia |  |
let-601/cuti-1 | h281 | Q > * | Cuticle regulatory protein | Both | Prediction |  |  |  |
let-602/T09B4.9 | h283 | W > * | translocase | RNAi | Prediction | TIMM44 |  |  |
let-604/mdt-18 | h293 | splice variant | Mediator subunit | RNAi | Prediction | MED18 | Â | Â |
let-605/cye-1 | h312 | W > * | E-type cyclin | Both | Prediction | CCNE1 |  |  |
let-614 | h138 | Â | Â | Â | Tested against F27C1.3 but did not confirm | Â | Â | Â |
let-376 | h130 | Â | Â | Â | Tested against F55F8.3 but did not confirm | Â | Â | Â |
let-375 | h241 | Â | Â | Â | Tested against imb-1 but did not confirm | Â | Â | Â |
let-387 | h87 | Â | Â | Â | Tested against pnk-1 but did not confirm | Â | Â | Â |
let-515 | h730 | Â | Â | Â | Tested against rpl-13 but did not confirm | Â | Â | Â |
let-501 | h714 | Â | Â | Â | Tested against rpl-4 but did not confirm | Â | Â | Â |
let-361 | h97 | Â | Â | Â | no candidate | Â | Â | Â |
let-531 | h733 | Â | Â | Â | no candidate | Â | Â | Â |
let-576 | h816 | Â | Â | Â | no candidate | Â | Â | Â |
let-518 | h316 | Â | Â | Â | no candidate | Â | Â | Â |
let-523 | h751 | Â | Â | Â | no candidate | Â | Â | Â |
let-525 | h874 | Â | Â | Â | no candidate | Â | Â | Â |
let-584 | h743 | Â | Â | Â | no candidate | Â | Â | Â |