Figure 3
Male and female brain region bionetwork cluster analysis and corresponding gene modules. Topological overlap matrixes of the gene co-expression network consisting of genes differentially expressed in F3 generation vinclozolin lineage rat brain as compared to F3 generation lineage Control animals. Genes in the rows and columns are sorted by an agglomerative hierarchical clustering algorithm. The different shades of color signify the strength of the connections between the nodes (from white signifying not significantly correlated to red signifying highly significantly correlated). Modules identified are colored along both column and row and are boxed. (a) Matrixes of combined network for male and female brain regions. (b) Matrixes of separate network for female amygdala (F-Amy), cingulate cortex (F-CngCTX), enterorhinal cortex (F-EnCTX), hippocampus (F-Hipp), olfactory bulbs (F-OlfB), and preoptic area-anterior hypothalamus (F-POAH). (c) Matrixes of separate network for male amygdala (M-Amy), cingulate cortex (M-CngCTX), enterorhinal cortex (M-EnCTX), hippocampus (M-Hipp), olfactory bulbs (M-OlfB), and preoptic area-anterior hypothalamus (M-POAH).