Evaluation of high throughput gene expression platforms using a genomic biomarker signature for prediction of skin sensitization

Table 2 List of chemical compounds used during evaluation of platforms

Compound	Abbrev.	Potency according to LLNA	Vehicle	GARD input concentration (μM)
*Sensitizers*
2-Aminophenol	2-AP	Strong	DMSO	100
2-nitro-1,4-phenylenediamine	NPDA	Strong	DMSO	300
p-Phenylenediamine	PPD	Strong	DMSO	75
Ethylenediamine	EDA	Moderate	Water	500
2-hydroxyethyl acrylate	2-HA	Moderate	Water	100
Eugenol	EUG	Weak	DMSO	300
Geraniol	GER	Weak	DMSO	500
Penicillin G	PEN G	Weak	Water	500
*Non-sensitizers*
1-Butanol	BUT		DMSO	500
Dimethyl formamide	DF		Water	500
Ethyl vanillin	EV		DMSO	500
Metyl salicylate	MS		DMSO	500
Propylene glycol	PG		Water	500
Salicylic acid	SA		DMSO	500
*Vehicle controls*
Water	dH₂O		-	-
Dimethyl sulfoxide	DMSO		-	-

List of chemical compounds used for evaluation of platforms. List includes information on sensitizing potency, vehicle, GARD input concentration and abbreviation for each chemical.

ISSN: 1471-2164