EPAS1 gene variants are associated with sprint/power athletic performance in two cohorts of European athletes

BMC Genomics

Table 2 Covariates identified in the MARS model excluding rs11689011

		Covariate	P-value¹	BIF²	Odds Ratio
Endurance athletes vs. controls	Russians	rs1867785*sex	0.00022	61.7	Other combinations	1 (ref)
	Russians	rs1867785*sex	0.00022	61.7	GA or GG in women	0.39 (0.24-0.65)
	Polish
	Russians + Polish
Sprint/power athletes vs. controls	Russians	rs4035887	0.0072	43.6	GA or GG	1 (ref)
		rs4035887	0.0072	43.6	AA	0.54 (0.34-0.88)
		rs1867785	0.0017	78.3	GA or GG	1 (ref)
		rs1867785	0.0017	78.3	AA	0.47 (0.25-0.84)
	Polish
	Russians + Polish	rs1867785	0.00016	90.1	GA + GG	1 (ref)
		rs1867785	0.00016	90.1	AA	0.53 (0.35-0.80)
		rs4035887*rs1867785	0.00016	52.6	Other combinations	1 (ref)
		rs4035887*rs1867785	0.00016	52.6	AA at rs4035887 and	0.61 (0.45-0.85)
					GA or GG at rs1867785

¹P-value obtained by logistic regression.
²Bootstrap Inclusion Fraction calculated after running 10000 MARS models on 10000 bootstrap samples. A BIF of 90.1 indicates that the covariate of interest was selected in 90.1% of the MARS models.
*denotes an interaction.

ISSN: 1471-2164