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Table 4 Genes which were down regulated in small atretic follicles with respect to healthy follicles†

From: Transcriptome profiling of granulosa cells from bovine ovarian follicles during atresia

Gene symbol Fold change Gene symbol Fold change Gene symbol Fold change
Cell Cycle
HAUS4 9.7 CASC5 4.1 FAM83D 3.4
KIFC1 7.2 *PTTG1 4.0 CDCA2 3.3
TOP2A 6.3 BUB1 3.9 KIF23 3.3
HJURP 5.6 SKA3 3.9 CENPF 3.3
CDCA8 4.6 TPX2 3.8 MCM10 3.3
MDC1 4.5 SGOL1 3.8 CDCA3 3.3
RAD51AP1 4.5 CDC20 3.8 OIP5 3.2
CENPE 4.5 GINS3 3.7 ASPM 3.2
ANAPC5 4.4 ASF1B 3.7 NCAPH 3.2
NUSAP1 4.3 CDC6 3.7 MAD2L1 3.1
MYO1D 4.3 ERCC6L 3.6 CKAP2 3.1
KLC2 4.3 CCNB1 3.6 *CENPA 3.1
BUB1B 4.2 PRCC 3.5 AURKB 3.0
CNNM2 4.2 CENPN 3.5   
Cell Death
TRIB2 6.5 RIPK3 4.8   
Cell Morphology
CKAP2L 4.7 SRGN 4.0 MAPT 3.3
PLP1 4.6 HMMR 3.8 PRC1 3.3
JAKMIP1 4.6 RSPH9 3.7 TNNC1 3.2
TMEM138 4.5 SYNPO 3.6 PHACTR1 3.1
ECT2 4.2 LEMD2 3.5 MYO5C 3.0
TMEM216 4.0 CDH26 3.5   
Cytokines, Hormones and Receptors
FGFR2 8.4 INHA 3.8 CCR3 3.2
F2RL2 5.9 ADRA1A 3.7 CHRM4 3.2
VEGFA 5.8 IL7 3.6 P2RY10 3.2
RHO 5.8 CD5 3.6 NR5A1 3.2
IL17RE 5.5 GPR128 3.6 OPN1LW 3.2
LTA 4.8 GPR61 3.6 AHR 3.2
IL18R1 4.6 GPR77 3.5 IL20RA 3.2
FSHR 4.4 FGF10 3.4 HTR1D 3.2
HTR2A 4.4 CCL11 3.4 FGFBP1 3.1
AMH 4.2 OPCML 3.4 TSHB 3.1
GPRC5A 4.2 CCL25 3.4 ASGR1 3.1
OPRM1 4.2 CCL28 3.4 HEG1 3.1
INHBA 4.2 FIGF 3.4 IL1A 3.1
NTRK3 4.1 CD72 3.3 IGF1 3.1
FST 4.0 ABP1 3.3 CASR 3.0
FSHB 4.0 EDNRA 3.3 GMFG 3.0
IL21 4.0 ITGB3 3.2 HTR4 3.0
BMP15 3.8 NGFR 3.2   
Directional Cell Growth
FAT1 3.6     
Extracellular Matrix and Synthesis
LAMC2 6.4 COL6A6 3.7 COL10A1 3.5
EPYC 4.3 TRAM2 3.6 *AMELX//AMELY 3.3
Intercellular and Cell to Matrix Adhesion
MUC15 5.7 CLDN6 3.8 DSG1 3.1
PRELP 4.5 CD33 3.5 PECAM1 3.1
*MCAM 4.0 SMAGP 3.5 EPDR1 3.1
*GLYCAM1 3.9 *BOLA-DQ2 3.3 CLEC4E 3.0
SELL 3.9 CD96 3.2   
Ion Transport
TTYH1 4.8 KCNE1 3.4 SLC25A34 3.1
FXYD7 4.3 P2RX5 3.2 CACNA1D 3.1
KCNJ15 3.5 TRPM6 3.2 *KCNIP2 3.0
Protein Trafficking
INSIG1 3.8 VPS52 3.2   
Proteolysis or Inhibition
*PTI 58.8 TROAP 3.5 DBC1 3.2
CPXM2 5.2 MMP7 3.4 TASP1 3.2
TFPI 5.1 ACE2 3.3 PGA5 3.1
PRSS22 4.4 CPB1 3.3 SERPINI2 3.1
CUL7 4.3 SPPL2B 3.2 MMP3 3.0
KLK4 4.1 SPAG5 3.2 TRIM8 3.0
USP28 3.8     
RNA Processing
DCP1A 3.6 U2SURP 3.0   
Transcription Regulation
ZFHX3 6.3 HAND1 3.8 BCORL1 3.2
HOXB2 4.6 NFE2L2 3.6 NCOA6 3.2
ZNF385A 4.5 SP100 3.6 EHMT2 3.2
CCNT1 4.5 UHRF1 3.5 CC2D1B 3.2
SRCAP 4.3 BCOR 3.5 IRF2BP1 3.2
LDB1 4.2 RFX5 3.4 NSD1 3.1
POLR3D 4.0 NOTCH4 3.4 TFAP2A 3.1
ELK1 4.0 ASB12 3.3 ZBTB4 3.1
VSX1 4.0 NFIA 3.3 POU1F1 3.1
VGLL1 3.8 HOXD9 3.2 ZNF274 3.0
Translation Regulation
YBX2 4.9 EEFSEC 3.3 EEF1A1 3.1
NARS 3.3     
Transport
AQP1 7.0 SLC12A8 4.0 SLC8A1 3.4
TRPA1 6.1 SLC5A9 4.0 EPB42 3.4
*ATP10A 6.1 PDYN 4.0 SYNGR3 3.3
TNPO1 6.0 SLC24A1 4.0 SLC6A9 3.2
ALB 5.7 RHBG 4.0 AP4B1 3.2
SLC27A3 5.5 ATP13A2 3.8 GOSR1 3.2
SLCO2B1 5.1 KIF20A 3.6 ATP4A 3.2
APOB 5.0 STRA6 3.6 PLLP 3.2
MAL2 4.6 CLDN16 3.5 FLVCR2 3.1
SLC4A2 4.5 SLC7A1 3.5 SLC37A2 3.0
ATP2B4 4.4 GC 3.4 SLC13A2 3.0
ABCD1 4.2 ENSA 3.4 SLC38A11 3.0
SLC16A3 4.1     
Other Enzymes
CYP19A1 19.8 CYP4F2 4.2 PNLIP 3.4
AOAH 15.1 PDE4D 4.1 PDE6G 3.3
*PDK4 9.7 GPT 4.1 TRNAU1AP 3.3
NOS2 8.8 PDP2 3.9 ALDH1L2 3.3
ISG20 8.4 DBT 3.9 PJA2 3.3
ALG3 7.8 LPO 3.9 WDR46 3.3
CHST8 7.0 ALOX12B 3.8 IPMK 3.2
HMGCS1 6.9 METTL7B 3.7 ST6GAL1 3.2
GCLC 6.9 *IGL@ 3.7 ALG5 3.2
CA14 6.8 *IGHG 3.7 CA5B 3.2
UGT2B17 6.5 ETNK2 3.6 ACAD10 3.2
AKR1C3 5.9 PIPOX 3.6 DIO1 3.2
GYLTL1B 5.7 RNF168 3.6 ACSM1 3.1
SCD 5.6 LHPP 3.6 GSTM4 3.1
GPX3 5.4 CYP21A2 3.6 RSAD2 3.1
CYP2C19 5.2 NQO1 3.6 ACSM2A 3.1
GPX2 5.0 METTL21B 3.5 SH3GL2 3.1
HSD17B1 4.8 GCNT1 3.5 SEPT4 3.1
*FHL3 4.7 LPPR2 3.5 UBE2C 3.1
LPL 4.6 BCAT1 3.5 RBBP8 3.1
PLA2G1B 4.5 BBOX1 3.5 B3GNT3 3.1
PPP3CC 4.5 PNLIPRP2 3.5 DUSP14 3.0
PDE6A 4.4 METTL2A 3.4 GNA14 3.0
FMO2 4.4 P4HA2 3.4 CPS1 3.0
TYRP1 4.3 GALNT13 3.4   
CMBL 4.2 DCT 3.4   
Other Signalling
IHH 7.1 MAP4K1 4.0 LAT 3.3
HLA-A 6.2 RIC3 3.8 PILRA 3.3
TBKBP1 6.2 CD84 3.8 GPSM3 3.2
*HSPA1A 5.7 SHCBP1 3.6 DNAJB1 3.1
TESPA1 5.4 GUCA1A 3.6 KIR2DL5A 3.1
JAK3 5.1 MTUS1 3.4 PEX11B 3.1
GUCY2F 4.6 DOK2 3.4 UPK1A 3.1
SKAP1 4.5 RPS6KA4 3.3 LY6G6C 3.1
RASGRP4 4.2 RGS3 3.3 FIGNL1 3.0
BCL9 4.0     
Other
CSN2 17.7 EMID1 4.3 GIMAP7 3.5
MZB1 10.1 CYLC1 4.3 GUCA2A 3.4
STAC3 6.8 CCDC159 4.3 PLEKHF2 3.4
CCDC3 6.3 C21orf62 4.2 IFI44L 3.4
C9orf152 5.9 C1orf170 4.2 ODZ3 3.4
AGR2 5.8 APOBEC4 4.2 MICA 3.3
STAC 5.6 VWA8 4.1 TMEM139 3.3
EFHD1 5.5 PEAR1 4.1 UBN2 3.3
MTHFSD 5.4 MPDZ 4.0 C6orf47 3.3
NXPH2 5.4 IFIT2 4.0 Btnl1 3.3
SPEF1 5.3 ELMOD3 4.0 CXorf64 3.3
CRISPLD2 5.2 PLEK 4.0 DENND2D 3.3
KLHL29 5.2 SOWAHA 3.9 CHAC1 3.3
MEX3C 5.0 GCA 3.8 BIRC5 3.2
CAMP 4.7 LY9 3.8 CAPSL 3.2
KIAA0101 4.6 CCDC132 3.7 *RSPH10B 3.2
HRG 4.6 CRP 3.6 ANKRD17 3.1
KLHL33 4.6 C16orf53 3.6 *RNFT1 3.1
CEP85 4.5 HYOU1 3.6 HYDIN 3.1
PTGFRN 4.5 RASGEF1A 3.6 ASPHD1 3.1
TMIGD2 4.5 PIP 3.6 CCDC97 3.0
C6 4.4 OLFML1 3.5 CCDC43 3.0
WDR76 4.4 FAM178A 3.5 *PA1 3.0
MOB3B 4.4 TAGLN3 3.2 MLKL 3.0
RBL2 3.8 TMED6 3.2 WDR87 3.0
  1. † Differentially expressed genes (≥ 3 fold, P < 0.05) as annotated based on the Entrez Gene database and categorised by function using the Benjamini-Hochberg post-hoc test for multiple corrections following one way ANOVA.
  2. *indicates genes determined from the Partek analysis based on the Affymetrix annotations which were not assigned identities by IPA.