Disruption of Mycobacterium avium subsp. paratuberculosis-specific genes impairs in vivo fitness

BMC Genomics

Table 4 LSP^Pgenes depleted in vivo (as defined in [13])

LSP^P	Region description	Average ratio	Standard deviation	Predicted function
4	MAP0856c (MAPK_2912)	0.0843	0.0720	H.P.
4	MAP0862 (MAPK_2906)	0.0189	0.0378	H.P.
4	MAP0865 (MAPK_2903)	0.0000	0.0000	Cell division protein
11	MAP2148 (MAPK_1620)	0.0653	0.0640	Phage integrase
11	MAP2150 (MAPK_1618)	0.0827	0.0087	Transposase
11	MAP2154c (MAPK_1614)	0.1038	0.0153	H.P.
11	MAP2157 (MAPK_1611)	0.1216	0.0910	Transposase
11	MAP2158 (MAPK_1610)	0.1255	0.0333	H.P.
12	MAP2185c (MAPK_1583)	0.1410	0.1087	Amidohydrolase
12	MAP2194 (MAPK_1574)	0.0787	0.0703	Mce family protein
14	MAP3731c (MAPK_0037)	0.0302	0.0509	ABC transporter ATP-binding Protein
14	MAP3733c (MAPK_0035)	0.1041	0.0890	H.P.
14	MAP3735c (MAPK_0033)	0.0557	0.0533	ABC transporter ATP-binding Protein
14	MAP3741 (MAPK_0027)	0.0039	0.0005	H.P.
14	MAP3742 (MAPK_0026)	0.0265	0.0178	H.P.
14	MAP3745 (MAPK_0023)	0.0104	0.0154	H.P.
14	MAP3750 (MAPK_0018)	0.0111	0.0057	MmpS1 family protein
14	MAP3751 (MAPK_0017)	0.0746	0.0970	transmembrane transport protein, MmpL4_5
14	MAP3757c (MAPK_0011)	0.0923	0.0679	H.P.
14	MAP3759c (MAPK_3761)	0.0836	0.0106	Tranposase
14	MAP3760c (n. a.)	0.0400	0.0065	H.P.
14	MAP3763c (MAPK_3765)	0.0372	0.0267	PapA2_3
14	MAP3764c (MAPK_3766)	0.1181	0.1928	Pks2
15	MAP3776c (MAPK_3778)	0.1353	0.2561	ABC transporter periplasmic solute binding protein
16	MAP3816 (MAPK_3818)	0.0701	0.0757	Phage integrase
16	MAP3817c (MAPK_3819)	0.1251	0.0114	H.P.

LSP^P genes depleted in vivo with an average ratio of less than 0.1 × median (0.153). Gene annotation by Li et al shown in second column with Wynne et al annotation in brackets. H.P. = Hypothetical protein, Mce = Mammalian cell entry, Mmp = Membrane protein, Pap = Polyketide associated protein, Pks = Polyketide synthase, n. a. = not annotated.

ISSN: 1471-2164